header

Effect of thymoquinone on Ü7 nicotinic acetylcholine receptor in LPS- induced neuroinflammatory Alzheimer's disease rat model /

Esraa Osama Abdelaziz Mostafa

Effect of thymoquinone on Ü7 nicotinic acetylcholine receptor in LPS- induced neuroinflammatory Alzheimer's disease rat model / Esrss Osama Abdelaziz Mostafa ; Supervised Ola Heikal , Lobna Abdelaal Kassem - Cairo : Esrss Osama Abdelaziz Mostafa , 2017 - 139 Leaves : charts , facsimiles ; 30cm

Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmacology and toxicology

Alzheimer's disease (AD) is a neurodegenerative disorder resulting from the loss of cholinergic nerurons in the brain. It has been reported that Ü7 nicotinic acetylcholine receptors(Ü7 nAChRs) play an important role in cognitive processes representing a durg target for treating congnitive deficits. Ü7 nAChRs agonists cause memory enhancement through phosphorylation of cAMP response element binding protein (CREB)