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Role of 3-Acetyl-11-Keto-Beta-Boswellic acid in counteracting LPS- induced neuro- inflammation via modulation of miRNA-155 /

Aya Shoukry sayed Ahmed

Role of 3-Acetyl-11-Keto-Beta-Boswellic acid in counteracting LPS- induced neuro- inflammation via modulation of miRNA-155 / Aya Shoukry sayed Ahmed ; Supervised Nesrine Salah Eldin Elsayed , Iman Emam Imer Gomaa - Cairo : Aya Shoukry sayed Ahmed , 2016 - 152 Leaves : charts , facsimiles ; 30cm

Thesis (Ph.D.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Biology

Neuro- inflammation is one of the most important factors underlying neurodegeneration which triggers oxidative stress state and the subsequent neuronal death. Lipopolysaccharide (LPS) is a potent inflammogen ehich causes cognitive dysfunction. Boswellia serrata was known many years ago as a powerful anti- inflammatory herbal drug. Its beneficial effect mainly arises from inhibition of 5-lipoxygenase (5-LO) enzyme