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Novel strychnine dimers as bivalent ligands targeting glycine receptors /

Liza Samir Samy Botros

Novel strychnine dimers as bivalent ligands targeting glycine receptors / متشابهات ستركنين ثنائية التركيب جديدة كمثبطات لمستقبلات الجلايسين Liza Samir Samy Botros ; Supervised Darius P. Zlotos - Cairo : Liza Samir Samy Botros , 2017 - 128 Leaves : charts ; 30cm

Thesis (M.Sc.) - German University - Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry

Strychnine in the major alkaloid from the seeds of Strychnos nux-vomica and strychnos ignati. As a natural product, its structure has been optimized for strong interactions with biological macromolecules through evolutionary selection. Its most pronounced pharmacological action is an antagonistic activity at glycine receptors (GlyRs)