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Analytical study on some antibiotic residues in waste water from pharmaceutical industries /

Heba Kamal Ibrahim Abdelhady

Analytical study on some antibiotic residues in waste water from pharmaceutical industries / دراسة تحليلية على بعض متبقيات المضادات الحيوية في مياه صرف مصانع الأدوية Heba Kamal Ibrahim Abdelhady ; Supervised Mohamed Abdelkawy Mohamed Ibrahim , Medhat Ahmed Alghobashy , Sherif Abdelnabi Abdelgawad - Cairo : Heba Kamal Ibrahim Abdel Hady , 2017 - 146 P. : charts ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

Realistic implementation of ion selective electrodes (ISEs) into environmental monitoring programs has always been a challenging task. This could be largely attributed to difficulties in validation of ISE assay results. In this study, the electrochemical response of amoxicillin trihydrate (AMX), ciprofloxacin hydrochloride (CPLX), trimethoprim (TMP), and norfloxacin (NFLX) was studied by the fabrication of sensitive membrane electrodes belonging to two types of ISEs, which are polyvinyl chloride (PVC) membrane electrodes and glassy carbon (GC) electrodes. The actual waste water samples were subjected to solid phase extraction (SPE) for pretreatment prior to the application of chromatographic techniques (HPLC and TLC-densitometry). On the other hand, the fabricated electrodes were successfully applied for quantification of the antibiotic residues in actual waste water samples without any pretreatment. This finding assures the suitability of the fabricated ISEs for environmental analysis



Antibiotic residues Ion selective electrode Waste water