Association analysis of FTO gene polymorphism and obesity risk among Egyptian children and adolescents /
Samar Samir Abdelrahman Abdelmajed Elkhateeb
Association analysis of FTO gene polymorphism and obesity risk among Egyptian children and adolescents / و خطر الإصابة بمرض السمنة بين الأطفال والمراهقين المصريين FTO تحليل الارتباط ما بين التعدد الشكلى فى جين Samar Samir Abdelrahman Abdelmajed Elkhateeb ; Supervised Mohamed Mohamed Mohamed Yousef , Somaia Mohamed Ismail - Cairo : Samar Samir Abdelrahman Abdelmajed Elkhateeb , 2018 - 93 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology
Background: Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity-associated (FTO) gene and obesity in adults and children in different ethnic groups. Objective: In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. Subjects and methods: We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. Results: The current study showed that there were no significant differences between the cases and controls in both variants of rs17817449 and rs9939609. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL
Fat mass and obesity associated gene (FTO) Obesity Variants
Association analysis of FTO gene polymorphism and obesity risk among Egyptian children and adolescents / و خطر الإصابة بمرض السمنة بين الأطفال والمراهقين المصريين FTO تحليل الارتباط ما بين التعدد الشكلى فى جين Samar Samir Abdelrahman Abdelmajed Elkhateeb ; Supervised Mohamed Mohamed Mohamed Yousef , Somaia Mohamed Ismail - Cairo : Samar Samir Abdelrahman Abdelmajed Elkhateeb , 2018 - 93 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology
Background: Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity-associated (FTO) gene and obesity in adults and children in different ethnic groups. Objective: In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. Subjects and methods: We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. Results: The current study showed that there were no significant differences between the cases and controls in both variants of rs17817449 and rs9939609. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL
Fat mass and obesity associated gene (FTO) Obesity Variants