The effect of dexmedetomidine on perfusion index and microcirculation in patients with severe sepsis and septic shock : Randomized controlled study /
Eslam Rasmy Abdelfattah
The effect of dexmedetomidine on perfusion index and microcirculation in patients with severe sepsis and septic shock : Randomized controlled study / تأثير عقار الديكسميتوميدين على منسب التروية و دوران الأوعية الدقيقة فى مرضى الأنتنان الحاد و الصدمة الأنتنانية : دراسة منظبه معشاه Eslam Rasmy Abdelfattah ; Supervised Walid Ibrahim Hamimy , Ahmed Mohamed Mukhtar , Mohamed Elayashy Mohamed - Cairo : Eslam Rasmy Abdelfattah , 2018 - 93 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
Introduction: The high mortality rate observed in sepsis is not only related to the quality of management but its also related to the complex nature of the disease. Loss of autoregulation and altered regional and microvascular blood flow jeopardize both central and peripheral tissue perfusion in septic shock. Ü-2 adrenergic receptor agonists have effects on immunity, inflammation, and coagulation. [7] Also, D. Memis and college[8] suggest that dexmedetomidine may prevent inflammatory effects in sepsis patients during sedation. Methods: All consecutive patients who were clinically suspected of having severe sepsis defined by the criteria of the American college of chest physicians/ society of critical care medicine consensus conference; were included. patients were randomly allocated to two groups (group I: dexmeditomidine) and (group II: midazolam group). Drugs was infused for 6 hours upon admission to intensive care unit (ICU), hemodynamic, central peripheral perfusion variables and microcirculatory variables were simultaneously recorded at baseline and 6 hours after drug infusion. Perfusion variables included; PI, blood lactate level, central venous oxygen saturation (ScVO2), and the difference between central venous carbon dioxide (PcvCO2) and arterial carbon dioxide (PaCO2) pressures (Pv-a CO2
Dexmedetomidine Microcirculation Septicshock
The effect of dexmedetomidine on perfusion index and microcirculation in patients with severe sepsis and septic shock : Randomized controlled study / تأثير عقار الديكسميتوميدين على منسب التروية و دوران الأوعية الدقيقة فى مرضى الأنتنان الحاد و الصدمة الأنتنانية : دراسة منظبه معشاه Eslam Rasmy Abdelfattah ; Supervised Walid Ibrahim Hamimy , Ahmed Mohamed Mukhtar , Mohamed Elayashy Mohamed - Cairo : Eslam Rasmy Abdelfattah , 2018 - 93 P. : facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia
Introduction: The high mortality rate observed in sepsis is not only related to the quality of management but its also related to the complex nature of the disease. Loss of autoregulation and altered regional and microvascular blood flow jeopardize both central and peripheral tissue perfusion in septic shock. Ü-2 adrenergic receptor agonists have effects on immunity, inflammation, and coagulation. [7] Also, D. Memis and college[8] suggest that dexmedetomidine may prevent inflammatory effects in sepsis patients during sedation. Methods: All consecutive patients who were clinically suspected of having severe sepsis defined by the criteria of the American college of chest physicians/ society of critical care medicine consensus conference; were included. patients were randomly allocated to two groups (group I: dexmeditomidine) and (group II: midazolam group). Drugs was infused for 6 hours upon admission to intensive care unit (ICU), hemodynamic, central peripheral perfusion variables and microcirculatory variables were simultaneously recorded at baseline and 6 hours after drug infusion. Perfusion variables included; PI, blood lactate level, central venous oxygen saturation (ScVO2), and the difference between central venous carbon dioxide (PcvCO2) and arterial carbon dioxide (PaCO2) pressures (Pv-a CO2
Dexmedetomidine Microcirculation Septicshock