Preparation of cellulosic nanomaterials from date palm stalks residues and their use in drug delivery systems /
Wafaa Seleim Abouelseoud Seleim
Preparation of cellulosic nanomaterials from date palm stalks residues and their use in drug delivery systems / تحضير مواد سليلوزية نانومترية من مخلفات سباط البلح و استخدامها في انظمة توصيل الدواء Wafaa Seleim Abou El-Seoud Seleim ; Supervised Magdy Sabaa Wadid Farag , Mohammad Lotfy Hassan - Cairo : Wafaa Seleim Abouelseoud Seleim , 2018 - 174 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
This investigation aimed to use the cellulose nanocrystals (CNC) and chitosan nanoparticles (CHNP) for developing controlled drug delivery systems of the anti-hyperglycemic drug Repaglinide (RPG) and non-steroidal anti-inflammatory drug Ketoprofen (KP) via ionic gelation method. CNC were isolated from date palm stalks by sulfuric acid hydrolysis with dimensions of 86-237 nm in length and 5-7 nm in width. Chemical modification of CNC by oxidation to introduce carboxylic groups and by amine functionalization to introduce amino groups on their surface was also carried out for further controlling of RPG and KP release. The prepared systems containing CHNP and the different cellulose nanocrytals showed high entrapment efficiency of up to ~ 98% and 80% for RPG and KP, respectiely. Addition of the different cellulose nanocrystals to CHNP affected the release of the RPG and KP to different degrees depending on the loading and kind of the nanocrystals used (non- modified, carboxylated or aminated). Kinetic studies suggested that the release of RPG and KP from the different formulations were best fitted to Higuchi model
cellulose nanocrystals (CNC) chitosan nanoparticles(CHNP) ionic gelation
Preparation of cellulosic nanomaterials from date palm stalks residues and their use in drug delivery systems / تحضير مواد سليلوزية نانومترية من مخلفات سباط البلح و استخدامها في انظمة توصيل الدواء Wafaa Seleim Abou El-Seoud Seleim ; Supervised Magdy Sabaa Wadid Farag , Mohammad Lotfy Hassan - Cairo : Wafaa Seleim Abouelseoud Seleim , 2018 - 174 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
This investigation aimed to use the cellulose nanocrystals (CNC) and chitosan nanoparticles (CHNP) for developing controlled drug delivery systems of the anti-hyperglycemic drug Repaglinide (RPG) and non-steroidal anti-inflammatory drug Ketoprofen (KP) via ionic gelation method. CNC were isolated from date palm stalks by sulfuric acid hydrolysis with dimensions of 86-237 nm in length and 5-7 nm in width. Chemical modification of CNC by oxidation to introduce carboxylic groups and by amine functionalization to introduce amino groups on their surface was also carried out for further controlling of RPG and KP release. The prepared systems containing CHNP and the different cellulose nanocrytals showed high entrapment efficiency of up to ~ 98% and 80% for RPG and KP, respectiely. Addition of the different cellulose nanocrystals to CHNP affected the release of the RPG and KP to different degrees depending on the loading and kind of the nanocrystals used (non- modified, carboxylated or aminated). Kinetic studies suggested that the release of RPG and KP from the different formulations were best fitted to Higuchi model
cellulose nanocrystals (CNC) chitosan nanoparticles(CHNP) ionic gelation