Possible protective effects of nano-coenzyme Q10 and nano-vitamin E against atorvastatin-induced myopathy in hyperlipidemic rats /
Sama Magdy Farrag
Possible protective effects of nano-coenzyme Q10 and nano-vitamin E against atorvastatin-induced myopathy in hyperlipidemic rats / التأثيرات الوقائية المحتملة لنانو كو إنزيم كيو10 و نانو الفيتامين هـ ضد الاعتلال العضلي المحدث بواسطة أتورفاستاتين في فرط دهون الدم في الجرذان Sama Magdy Farrag ; Supervised Ezz Eldeen Saeed Eldenshary , Noha Nagah Nassar , Mohamed Abdallah Hamzawy - Cairo : Sama Magdy Farrag , 2018 - 140 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 (CoQ10) and nano vitamin E. Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants 2reduced glutathione (GSH) and superoxide dismutase (SOD)3 were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination
Atrovastatin Co Q10 Nanoparticulate
Possible protective effects of nano-coenzyme Q10 and nano-vitamin E against atorvastatin-induced myopathy in hyperlipidemic rats / التأثيرات الوقائية المحتملة لنانو كو إنزيم كيو10 و نانو الفيتامين هـ ضد الاعتلال العضلي المحدث بواسطة أتورفاستاتين في فرط دهون الدم في الجرذان Sama Magdy Farrag ; Supervised Ezz Eldeen Saeed Eldenshary , Noha Nagah Nassar , Mohamed Abdallah Hamzawy - Cairo : Sama Magdy Farrag , 2018 - 140 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
Statins are the most widely used to lower elevated low-density lipoprotein levels and preventing cardiovascular diseases in humans. However, about 20% of patients treated with this medication suffer from statin-related myalgia. To this end, this study investigated the potential effect of nano-particulate formulation in alleviating the muscles and liver damage either alone or when co-administered with nano coenzyme Q10 (CoQ10) and nano vitamin E. Male Wistar rats were fed normal diet or high-fat diet for 12 weeks, following which rats were treated with either (i) atorvastatin (5 or 20 mg/kg/day, p.o.) or (ii) atorvastatin with CoQ10 (10 mg/kg/day, p.o.) (iii) and/or vitamin E (30 mg/kg/day, p.o.) in free particle or nanoparticle forms for another 4 weeks. In all rats, serum total cholesterol (CH), triglycerides (TGs), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), creatine kinase (CK), albumin (ALB), as well as hepatic malondialdehyde (MDA) and antioxidants 2reduced glutathione (GSH) and superoxide dismutase (SOD)3 were measured. Additionally quadriceps muscles and liver tissues were used for histopathological examination
Atrovastatin Co Q10 Nanoparticulate