Study of the potential of arachidonic acid to naturally eradicate schistosoma /
Violette Said Hanna Youssef
Study of the potential of arachidonic acid to naturally eradicate schistosoma / دراسة قدرة حمض الاراكيدونيك على التخلص الطبيعى من دودة البلهارسيا Violette Said Hanna Youssef ; Supervised Ebtisam Abdelaziz Hafez , Azza Mahmoud Gawish , Hatem Abdelmoneim Tallima - Cairo : Violette Said Hanna Youssef , 2018 - 100 P. : photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology
Schistosoma mansoni and Schistosoma haematobium are parasitic flatworms that infect millions of people in developing countries. A recent report has proved that resistance of the water-rat to S. mansoni might be ascribed to arachidonic acid (ARA)-rich lipids in liver. Reports have shown that ARA is a safe and effective schistosomicide in vitro, and in vivo. Accordingly, it was proposed that ARA increased levels might be responsible for natural attrition of S. mansoni and S. haematobium in resistant rodents. Therefore, the levels of ARA in serum, lung, and liver of rats (resistant) and mice (susceptible) before and post infection with S. mansoni and between mice (semi-permissive) and hamster (susceptible) before and post infection with S. haematobium were compared. Significant (P<0.05) correlation was recorded between ARA content and rodent resistance to schistosomes, implicating ARA as an endoschistosomicide
Rat schistosomiasis Schistosoma haematobium Schistosoma mansoni
Study of the potential of arachidonic acid to naturally eradicate schistosoma / دراسة قدرة حمض الاراكيدونيك على التخلص الطبيعى من دودة البلهارسيا Violette Said Hanna Youssef ; Supervised Ebtisam Abdelaziz Hafez , Azza Mahmoud Gawish , Hatem Abdelmoneim Tallima - Cairo : Violette Said Hanna Youssef , 2018 - 100 P. : photographs ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biotechnology
Schistosoma mansoni and Schistosoma haematobium are parasitic flatworms that infect millions of people in developing countries. A recent report has proved that resistance of the water-rat to S. mansoni might be ascribed to arachidonic acid (ARA)-rich lipids in liver. Reports have shown that ARA is a safe and effective schistosomicide in vitro, and in vivo. Accordingly, it was proposed that ARA increased levels might be responsible for natural attrition of S. mansoni and S. haematobium in resistant rodents. Therefore, the levels of ARA in serum, lung, and liver of rats (resistant) and mice (susceptible) before and post infection with S. mansoni and between mice (semi-permissive) and hamster (susceptible) before and post infection with S. haematobium were compared. Significant (P<0.05) correlation was recorded between ARA content and rodent resistance to schistosomes, implicating ARA as an endoschistosomicide
Rat schistosomiasis Schistosoma haematobium Schistosoma mansoni