Role of long non coding rnas expression in development of atherosclerosis in Egyptian systemic lupus erythematosus patients /
Mai Ahmed Abdelmawla
Role of long non coding rnas expression in development of atherosclerosis in Egyptian systemic lupus erythematosus patients / دور التعبير الجيني لجزيئات الحمض النووي الريبوزي الطويلة غير المشفرة للبروتينات وإرتباطه بنشوء تصلب الشرايين عند مرضي الذئبة الحمراء المصريين Mai Ahmed Abdelmawla ; Supervised Amira A. Shaheen , Sherine M. Rizk , Mary W. Fawzy - Cairo : Mai Ahmed Abdelmawla , 2018 - 77 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
Although long non-coding RNAs (lncRNAs) have emerged as potential regulators in the development of atherosclerosis, their precise role in setting of this complication in systemic lupus erythematosus (SLE) is largely unknown. So our study aimed to quantify the expression level of three lncRNAs which are known to be relevant to atherosclerosis (ANRIL, NOS3-AS and APOA1-AS) in Egyptian SLE patients and to assess their relationship with atherogenic and inflammatory biomarkers. The circulating levels of these lncRNAs were assessed using RT-PCR, in addition to measurement of E-selectin, V-CAM1, oxidized low density lipoprotein (oxLDL), total nitric oxide (NOx) and lipid profile in 65 SLE patients (35 atherosclerotic and 30 non atherosclerotic) beside 35 healthy control subjects of matched age and sex. The expression levels of these lncRNAs were higher in SLE patients than in healthy controls. Importantly, a higher over-expression of these lncRNAs was noticed in atherosclerotic SLE patients than in non atherosclerotic ones
ANRIL Atherosclerosis Systemic lupus erythematosus
Role of long non coding rnas expression in development of atherosclerosis in Egyptian systemic lupus erythematosus patients / دور التعبير الجيني لجزيئات الحمض النووي الريبوزي الطويلة غير المشفرة للبروتينات وإرتباطه بنشوء تصلب الشرايين عند مرضي الذئبة الحمراء المصريين Mai Ahmed Abdelmawla ; Supervised Amira A. Shaheen , Sherine M. Rizk , Mary W. Fawzy - Cairo : Mai Ahmed Abdelmawla , 2018 - 77 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
Although long non-coding RNAs (lncRNAs) have emerged as potential regulators in the development of atherosclerosis, their precise role in setting of this complication in systemic lupus erythematosus (SLE) is largely unknown. So our study aimed to quantify the expression level of three lncRNAs which are known to be relevant to atherosclerosis (ANRIL, NOS3-AS and APOA1-AS) in Egyptian SLE patients and to assess their relationship with atherogenic and inflammatory biomarkers. The circulating levels of these lncRNAs were assessed using RT-PCR, in addition to measurement of E-selectin, V-CAM1, oxidized low density lipoprotein (oxLDL), total nitric oxide (NOx) and lipid profile in 65 SLE patients (35 atherosclerotic and 30 non atherosclerotic) beside 35 healthy control subjects of matched age and sex. The expression levels of these lncRNAs were higher in SLE patients than in healthy controls. Importantly, a higher over-expression of these lncRNAs was noticed in atherosclerotic SLE patients than in non atherosclerotic ones
ANRIL Atherosclerosis Systemic lupus erythematosus