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Efficacy of high intensity interval training on endothelial function in diabetics with peripheral arterial insufficiency /

Hend Salem Ahmed

Efficacy of high intensity interval training on endothelial function in diabetics with peripheral arterial insufficiency / فعالية التمرينات المتقطعة عالية الشدة على وظيفة بطانة الاوعية الدموية فى مرضى السكرى مع قصور الشرايين الطرفية Hend Salem Ahmed ; Supervised Zeinab Mohammed Helmy , Heba Ahmed Ali Abdeen , Manal Ahmed Mohamed - Cairo : Hend Salem Ahmed , 2019 - 106 P. : charts , facsimiles ; 25cm

Thesis (Ph.D.) - Cairo University - Faculty of Physical Therapy - Department of Physical Therapy for Cardiopumonary and Geriatrics Disorders

Background and purpose: Peripheral Arterial Disease (PAD) due to diabetes affects quality of life, contributing to long-term disability and functional impairment that is often severe; Patients with claudication have a slower walking speed and a limited walking distance and impaired endothelial function. This may result in a cycle of disability with progressive deconditioning. High Intensity Interval Training (HIIT) has been shown to induce significant improvements in diabetic patients with PAD. Aim of the study : to investigate the effect of HIIT on pain free walking time, maximum walking time, maximum walking distance and nitric oxide in diabetics with PAD. Materials and methods: Thirty eligible male patients with PAD secondary to type 2 diabetes were selected from National Heart Institute (peripheral vascular outpatient clinic) , their ages ranged from 50-60 years old, their Body Mass Index (BMI) <30 kg/m2, their Ankle Brachial Index (ABI) ranged between (0.6) and (0.9), had intermittent claudication (IC) ,they were randomly assigned into two groups : study group which received HIIT for 5-30 min at 85-90% of the maximal heart rate, three times per week for 12 weeks in addition to their traditional medical treatment and received instructions about risk factor modification (n=15) and control group which received instructions about risk factor modification in addition to their traditional medical treatment (n=15), Before and after intervention, the following measures were obtained: pain free walking time, maximum walking time, maximum walking distance and nitric oxide



High Intensity Interval Training Intermittent Claudication Peripheral Arterial Disease