Chemical and biological investigation of certain plants belonging to genera caralluma and huernia (Family Asclepiadaceae) growing in Yemen /
Akram Ali Mohamed Shalabi
Chemical and biological investigation of certain plants belonging to genera caralluma and huernia (Family Asclepiadaceae) growing in Yemen / تقييم كيميائى وبيولوجى لبعض النباتات التى تنتمى الى جنس الكارلوما والهرنيا (العائلة العشارية) التى تنمو فى اليمن Akram Ali Mohamed Shalabi ; Supervised Essam A. Abdelsattar , Fatma Salem Elsakhawy , Ali Mahmoud Elhalawany - Cairo : Akram Ali Mohamed Shalabi , 2020 - 234 P. : charts , facimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
Asclepiadaceae species have been reported to include several biologically active compounds such as steroid C21, which comprise the largest class of secondary plant substances. Therefore, this family is a productive source of pregnane glycosides, which they can be exploited for the treatment of many diseases such as anti-cancer, anti-obesity and antidiabetic. This study provided a detailed report on the characterization of Caralluma hexagona Lavranos, Caralluma eremastrum O. Schwartz or Huernia macrocarpa (A. Richard) Sprenger as well as the isolation and characterization of isolated compounds from the CH₂Cl₂ fraction of C. hexagona. On other hand, the crude aqueous and methanolic extracts and methanolic fractions of all species and isolated compounds were evaluated for their possible anti-metabolic syndrome in in vitro by measuring their antioxidant capacity and inhibitory activities against Ü-glucosidase and pancreatic lipase enzymes, and inhibition of AGEs generation through BSAfructose (bovine serum albumin), BSA-methylglyoxal, and arginine methylglyoxal models and in vivo using high fat diet/streptozotocin-induced metabolic syndrome (MetS) rats. In vitro antiausterity activity also studied. Phytochemical characterization results showed that the greatest steroidal content was observed for the CH₂Cl₂ fractions. The investigation of the CH₂Cl₂ fraction of C. hexgaona led to the isolation and identification of seven new pregnane glycosides were termed Hexagonaside I - VII, along with four known compounds luteolin 4`-O-neohesperidoside, apigenin-8-C-neohesperoside, Ý-sitosterol and Ý-sitosterol glucoside. Regarding the enzyme assays, CH₂Cl₂ fractions showed the most potent Ü-glucosidase and lipase inhibitory effects
Family Asclepiadaceae Genera caralluma Huernia
Chemical and biological investigation of certain plants belonging to genera caralluma and huernia (Family Asclepiadaceae) growing in Yemen / تقييم كيميائى وبيولوجى لبعض النباتات التى تنتمى الى جنس الكارلوما والهرنيا (العائلة العشارية) التى تنمو فى اليمن Akram Ali Mohamed Shalabi ; Supervised Essam A. Abdelsattar , Fatma Salem Elsakhawy , Ali Mahmoud Elhalawany - Cairo : Akram Ali Mohamed Shalabi , 2020 - 234 P. : charts , facimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
Asclepiadaceae species have been reported to include several biologically active compounds such as steroid C21, which comprise the largest class of secondary plant substances. Therefore, this family is a productive source of pregnane glycosides, which they can be exploited for the treatment of many diseases such as anti-cancer, anti-obesity and antidiabetic. This study provided a detailed report on the characterization of Caralluma hexagona Lavranos, Caralluma eremastrum O. Schwartz or Huernia macrocarpa (A. Richard) Sprenger as well as the isolation and characterization of isolated compounds from the CH₂Cl₂ fraction of C. hexagona. On other hand, the crude aqueous and methanolic extracts and methanolic fractions of all species and isolated compounds were evaluated for their possible anti-metabolic syndrome in in vitro by measuring their antioxidant capacity and inhibitory activities against Ü-glucosidase and pancreatic lipase enzymes, and inhibition of AGEs generation through BSAfructose (bovine serum albumin), BSA-methylglyoxal, and arginine methylglyoxal models and in vivo using high fat diet/streptozotocin-induced metabolic syndrome (MetS) rats. In vitro antiausterity activity also studied. Phytochemical characterization results showed that the greatest steroidal content was observed for the CH₂Cl₂ fractions. The investigation of the CH₂Cl₂ fraction of C. hexgaona led to the isolation and identification of seven new pregnane glycosides were termed Hexagonaside I - VII, along with four known compounds luteolin 4`-O-neohesperidoside, apigenin-8-C-neohesperoside, Ý-sitosterol and Ý-sitosterol glucoside. Regarding the enzyme assays, CH₂Cl₂ fractions showed the most potent Ü-glucosidase and lipase inhibitory effects
Family Asclepiadaceae Genera caralluma Huernia