Utility of active halogenated compounds in synthesis of some fused heterocyclic compounds with expected biological activities /
Mirna Talaat Helmy Saadan
Utility of active halogenated compounds in synthesis of some fused heterocyclic compounds with expected biological activities / أستخدام المركبات الهالوجينيه النشطة فى تحضير بعض المركبات الملتحمة غيرمتجانسة الحلقة و المتوقع لها نشاطات بيولوجيه Mirna Talaat Helmy Saadan ; Supervised Hamdi M. Hassaneen , Fatma Mohamed saleh ali - Cairo : Mirna Talaat Helmy Saadan , 2020 - 113 P . : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
The present dissertation includes the results of the synthesis of new heterocyclic compounds using N,2-diaryldiazene-1-carbohydrazonoyl chlorides and other hydrazonoyl halides. The first part of the thesis concerned with using of N,2-diaryldiazene-1-carbohydrazonoyl chlorides in synthesis of novel 5-phenyldiazenyl-1,3,4-thiadiazole derivatives, 3-phenyldiazenyl spiro heterocycles and 3-phenyldiazenyl-1H-pyrazole derivatives. For this purpose reaction of 2- ((methylthio)carbonthioyl)hydrazones 7 with N,2-diaryldiazene-1-carbohydrazonoyl chlorides 1,2 at room temperature in absolute ethanol in the presence of triethylamine afforded the corresponding 1,3,4-thiadiazoles 11,12 (Scheme 1). Also, the latter products 11,12 were prepared by treatment of 2-hydrazono-3-aryl-5-(aryldiazenyl)-2,3-dihydro-1,3,4-thiadiazoles 9,10 with the appropriate aldehydes and ketones in 2-propanol in the presence of few drops of hydrochloric acid at reflux. The latter products 9,10 were prepared via stirring of methyl hydrazinecarbodithioate 6 with N,2-diaryldiazene-1-carbohydrazonoyl chlorides 1,2 at room temperature in absolute ethanol in the presence of triethylamine (Scheme 1)
Chloroformazans Cycloaddition reaction Methyl hydrazinecarbodithioate
Utility of active halogenated compounds in synthesis of some fused heterocyclic compounds with expected biological activities / أستخدام المركبات الهالوجينيه النشطة فى تحضير بعض المركبات الملتحمة غيرمتجانسة الحلقة و المتوقع لها نشاطات بيولوجيه Mirna Talaat Helmy Saadan ; Supervised Hamdi M. Hassaneen , Fatma Mohamed saleh ali - Cairo : Mirna Talaat Helmy Saadan , 2020 - 113 P . : charts ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Organic Chemistry
The present dissertation includes the results of the synthesis of new heterocyclic compounds using N,2-diaryldiazene-1-carbohydrazonoyl chlorides and other hydrazonoyl halides. The first part of the thesis concerned with using of N,2-diaryldiazene-1-carbohydrazonoyl chlorides in synthesis of novel 5-phenyldiazenyl-1,3,4-thiadiazole derivatives, 3-phenyldiazenyl spiro heterocycles and 3-phenyldiazenyl-1H-pyrazole derivatives. For this purpose reaction of 2- ((methylthio)carbonthioyl)hydrazones 7 with N,2-diaryldiazene-1-carbohydrazonoyl chlorides 1,2 at room temperature in absolute ethanol in the presence of triethylamine afforded the corresponding 1,3,4-thiadiazoles 11,12 (Scheme 1). Also, the latter products 11,12 were prepared by treatment of 2-hydrazono-3-aryl-5-(aryldiazenyl)-2,3-dihydro-1,3,4-thiadiazoles 9,10 with the appropriate aldehydes and ketones in 2-propanol in the presence of few drops of hydrochloric acid at reflux. The latter products 9,10 were prepared via stirring of methyl hydrazinecarbodithioate 6 with N,2-diaryldiazene-1-carbohydrazonoyl chlorides 1,2 at room temperature in absolute ethanol in the presence of triethylamine (Scheme 1)
Chloroformazans Cycloaddition reaction Methyl hydrazinecarbodithioate