Impact of microbial infection on epithelial mesenchymaltransition mechanism as a vehicle of bladder cancer metastasis : A molecular biology study /
Romaila Ahmed Mahmoud Abdeleraouf
Impact of microbial infection on epithelial mesenchymaltransition mechanism as a vehicle of bladder cancer metastasis : A molecular biology study / دراسة جزيئية : تأثير العدوي الميكروبية على آلية تحول خلايا الظاهرية الى خلايا وسيطة كوسيلة لانتشار مرض سرطان المثانة البولية Romaila Ahmed Mahmoud Abdeleraouf ; Supervised Salama A. Ouf , Bedier Alieldien Elbaz , Khaled Fawzy Alyasargy - Cairo : Romaila Ahmed Mahmoud Abdeleraouf , 2021 - 188 P. : charts , facsmilies ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology
ROS levels are triggered in cancer cells because of bacteria that led to increase in UCP2 to adjust ROS levels. This enhances PDK1 to downregulate PDH in order to block OXPHOS in favor of glycolysis. That results in aberration in mitochondrial function and decrease of AMPK enzyme, while MCT1 elevates to be able to export the produced lactate to ECM. ECM now became more acidic and ready for morphological changes. This process occurs concomitantly with EMT as it provides the cell rapid ATP and energy required for transdifferentiation like EMT and stemness
Bacteria Bladder cancer Epithelial mesenchymal transition
Impact of microbial infection on epithelial mesenchymaltransition mechanism as a vehicle of bladder cancer metastasis : A molecular biology study / دراسة جزيئية : تأثير العدوي الميكروبية على آلية تحول خلايا الظاهرية الى خلايا وسيطة كوسيلة لانتشار مرض سرطان المثانة البولية Romaila Ahmed Mahmoud Abdeleraouf ; Supervised Salama A. Ouf , Bedier Alieldien Elbaz , Khaled Fawzy Alyasargy - Cairo : Romaila Ahmed Mahmoud Abdeleraouf , 2021 - 188 P. : charts , facsmilies ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Botany and Microbiology
ROS levels are triggered in cancer cells because of bacteria that led to increase in UCP2 to adjust ROS levels. This enhances PDK1 to downregulate PDH in order to block OXPHOS in favor of glycolysis. That results in aberration in mitochondrial function and decrease of AMPK enzyme, while MCT1 elevates to be able to export the produced lactate to ECM. ECM now became more acidic and ready for morphological changes. This process occurs concomitantly with EMT as it provides the cell rapid ATP and energy required for transdifferentiation like EMT and stemness
Bacteria Bladder cancer Epithelial mesenchymal transition