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Development and validation of spectrophotometric and spectrofluorimetric methods for determination of some selected drugs /

Shrouk Essam Ahmed Elgmaal

Development and validation of spectrophotometric and spectrofluorimetric methods for determination of some selected drugs / تطوير وإثبات مصداقيه بعض الطرائق للقياس الطيفى والقياس اللصفى لبعض الأدوية المختارة Shrouk Essam Ahmed Elgmaal ; Supervised Yasser Shaker Elsaharty , Nadia Mohamed Mostafa , Shereen Ahmed Boltia - Cairo : Shrouk Essam Ahmed Elgmaal , 2021 - 200 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry

This thesis is concerned with the analysis of some pharmaceutical compounds. It comprises three parts, part I is about general introduction of cephalosporin, while part II is about the litrature review of cefdinir and stability indicating methods for determination of cefdinir. Part III is concerned with the simultaneous analysis of a binary mixture of phenobarbital sodium and acefylline piperazine in the presence of dosage form additive (methylparaben). Various analytical techniques were used; spectrofluorimetry, spectrophotometry, chemometry, thin layer chromatography (TLC) and high performance liquid chromatography (HPLC).The proposed methods were simple, accurate, and reproducible, which would be feasible, and sensitive for the determination of the studied drugs. The proposed methods were validated according to ICH-guidelines



Chemmometry Spectrofluorimetry Spectrophotometry