Study effects of adding cabergoline by different doses to coasting reduce the incidence ovarian hyperstimulation syndrome : A randomized controlled study /
Ahmed Othman Ahmed Sayed Ahmed
Study effects of adding cabergoline by different doses to coasting reduce the incidence ovarian hyperstimulation syndrome : A randomized controlled study / دراسة آثار إضافة كابر جولين بجرعات مختلفة إلى إيقاف المنشط فى تحفيظ نسبة متلازمة فرط الأستجابة للمبيض : دراسة عشوائية منضبطة Ahmed Othman Ahmed Sayed Ahmed ; Supervised Tarek Fawzy , Ahmed Maged , Abdelghany Mohamed - Cairo : Ahmed Othman Ahmed Sayed Ahmed , 2020 - 126 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics
Background:Ovarian hyperstimulation syndrome (OHSS) is a potentially severe iatrogenic complication of controlled ovarian stimulation. Combining coasting and cabergoline may be beneficial for preventing OHSS, but this has not been well investigated. Objectives:To compare the effectiveness and safety of combined cabergoline and coasting versus coasting alone for preventing OHSS in high-risk women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods:The present double-blinded randomized controlled trial was conducted at Al-Ahram Fertility Center (Mansoura, Egypt) between January 2016 and December 2018. 200 patients undergoing IVF/ICSI at high risk of OHSS were equally randomized to coasting or combined coasting and cabergoline. The main measured outcomes were the rate and severity of OHSS, number of retrieved oocytes, number and quality of embryos, as well as rates of fertilization, implantation,chemical, and clinical pregnancy. Results:The combination group has a lower rate of OHSS (4% vs. 18%, p 0.001) and higher number of good embryos (12.1 ±3.93 vs. 6.9 ±2.67; p< 0.00). There were no significant differences between the two groups in the number of retrieved oocytes as well as the rates of fertilization, implantation,chemical, and clinical pregnancy
Cabergoline Hyperstimulation syndrome Ovarian hyperstimulation syndrome (OHSS)
Study effects of adding cabergoline by different doses to coasting reduce the incidence ovarian hyperstimulation syndrome : A randomized controlled study / دراسة آثار إضافة كابر جولين بجرعات مختلفة إلى إيقاف المنشط فى تحفيظ نسبة متلازمة فرط الأستجابة للمبيض : دراسة عشوائية منضبطة Ahmed Othman Ahmed Sayed Ahmed ; Supervised Tarek Fawzy , Ahmed Maged , Abdelghany Mohamed - Cairo : Ahmed Othman Ahmed Sayed Ahmed , 2020 - 126 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Gynecology and Obstetrics
Background:Ovarian hyperstimulation syndrome (OHSS) is a potentially severe iatrogenic complication of controlled ovarian stimulation. Combining coasting and cabergoline may be beneficial for preventing OHSS, but this has not been well investigated. Objectives:To compare the effectiveness and safety of combined cabergoline and coasting versus coasting alone for preventing OHSS in high-risk women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Methods:The present double-blinded randomized controlled trial was conducted at Al-Ahram Fertility Center (Mansoura, Egypt) between January 2016 and December 2018. 200 patients undergoing IVF/ICSI at high risk of OHSS were equally randomized to coasting or combined coasting and cabergoline. The main measured outcomes were the rate and severity of OHSS, number of retrieved oocytes, number and quality of embryos, as well as rates of fertilization, implantation,chemical, and clinical pregnancy. Results:The combination group has a lower rate of OHSS (4% vs. 18%, p 0.001) and higher number of good embryos (12.1 ±3.93 vs. 6.9 ±2.67; p< 0.00). There were no significant differences between the two groups in the number of retrieved oocytes as well as the rates of fertilization, implantation,chemical, and clinical pregnancy
Cabergoline Hyperstimulation syndrome Ovarian hyperstimulation syndrome (OHSS)