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A comparative evaluation of the effect of pretreatment dexamethasone versus placebo on post-endodontic pain and success of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis : A blinded randomized clinical trial therapeutic study /

Mai Mohamed Safei Eldin Sayed

A comparative evaluation of the effect of pretreatment dexamethasone versus placebo on post-endodontic pain and success of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis : A blinded randomized clinical trial therapeutic study / دراسة سريرية العشوائية علاجية كفيفة : تقييم مقارن لتأثير ديكساميثازون المعالج مقابل الدواء الوهمى على ألم ما بعد علاج العصب و نجاح كتلة العصب السنخية السفلية فى اضراس الفك السفلى مع اعراض التهاب اللب لا رجعة فيه Mai Mohamed Safei Eldin Sayed ; Supervised Manar Yehia Fouda , Nehal Nabil Roshdy - Cairo : Mai Mohamed Safei Eldin Sayed , 2019 - 74 P . : charts ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Endodontics

Aim: Evaluate the effect of using a preoperative, single oral dose of dexamethasone versus placebo on postoperative pain which is a primary outcome demonstrated immediately after the treatment, 6, 12, 24, 48 hours postoperatively and success of inferior alveolar nerve block which is the secondary outcome demonstrated at access preparation and pulp extirpation in mandibular molars with symptomatic irreversible pulpitis.Materials and methods: Thirty two patients were randomly assigned into two equal groups. Patients were asked to record his /her pain level before starting the endodontic treatment using the [Numerical Rating Scale (NRS)]. Half an hour after oral administration of the tablets, the tooth was anaesthetized by inferior alveolar nerve block. They were instructed to make a mark on the point that was representing their pain level and to complete a pain diary at access cavity, pulp extirpation, immediately after treatment completion, 6, 12, 24, and 48 hours after the commencement of treatment. Results: Results showed that either pre-operatively, at access, at pulp extirpation, post-operatively, after 6, 12, 24 as well as 48 hours; there was no statistically significant difference between the two groups. Conclusion: Within the limitation of this study, it could be concluded that preoperative administration of a single dose of 0.5 mg dexamethasone did not seem to affect the intensity of postoperative pain or the anesthetic success of inferior alveolar nerve block using 2% mepivacaine with 1:100,000 epinephrine for patients suffering from symptomatic irreversible pulpitis in mandibular molars



Dexamethasone versus placebo Numerical Raing Scale (NRS) Post-endodontic pain