Immunohistochemical expression of cyclooxgynase-2 and transforming growth factor-Ý1 in adenoid cystic carcinoma of salivary gland : In vitro study /
Amal Mostafa Sayed Mostafa
Immunohistochemical expression of cyclooxgynase-2 and transforming growth factor-Ý1 in adenoid cystic carcinoma of salivary gland : In vitro study / التوزيع المناعى الهيستوكيميائى للسيكلو-اوكسيجينيز- 2و معامل النمو الانتقالى بيتا- 1 فى السرطان الشبه غدى التكيسى للغدد اللعابية: دراسه في المختبر Amal Mostafa Sayed Mostafa ; Supervised Amal Hassan Abdelrahman , Reham Salah Hamed - Cairo : Amal Mostafa Sayed Mostafa , 2018 - 107 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology
The aim of the present study was to investigate the immunohistochemical expression of TGF-Ý1 and COX-2 in different variants of ACC (cribriform, tubular/trabecular and solid) and also correlate the expression of the two markers with each other. A total of 30 specimens were collected. The standard avidin-biotinperoxidase technique has been used in the present study for detection of TGF- Ý1and COX-2, the immunostaining of these markers were evaluated by an image analyzer computer system. The study demonstrated that COX-2 and TGF-Ý1expression was significantly increased in solid variant of ACC than other patterns and thus concluded that COX-2 and TGF-Ý1expression are directly related to ACC histopathological grade. The study also showed a significant direct correlation between the immunostaining of TGF-Ý1 and COX-2.In most of cases the increase in COX-2 expression is associated with increase in TGF-Ý1expression, which may indicate that TGF-Ý1 induce the expression of COX-2
Cyclooxgynase-2 Factor-Ý1 Salivary gland
Immunohistochemical expression of cyclooxgynase-2 and transforming growth factor-Ý1 in adenoid cystic carcinoma of salivary gland : In vitro study / التوزيع المناعى الهيستوكيميائى للسيكلو-اوكسيجينيز- 2و معامل النمو الانتقالى بيتا- 1 فى السرطان الشبه غدى التكيسى للغدد اللعابية: دراسه في المختبر Amal Mostafa Sayed Mostafa ; Supervised Amal Hassan Abdelrahman , Reham Salah Hamed - Cairo : Amal Mostafa Sayed Mostafa , 2018 - 107 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Oral and Dental Medicine - Department of Oral Pathology
The aim of the present study was to investigate the immunohistochemical expression of TGF-Ý1 and COX-2 in different variants of ACC (cribriform, tubular/trabecular and solid) and also correlate the expression of the two markers with each other. A total of 30 specimens were collected. The standard avidin-biotinperoxidase technique has been used in the present study for detection of TGF- Ý1and COX-2, the immunostaining of these markers were evaluated by an image analyzer computer system. The study demonstrated that COX-2 and TGF-Ý1expression was significantly increased in solid variant of ACC than other patterns and thus concluded that COX-2 and TGF-Ý1expression are directly related to ACC histopathological grade. The study also showed a significant direct correlation between the immunostaining of TGF-Ý1 and COX-2.In most of cases the increase in COX-2 expression is associated with increase in TGF-Ý1expression, which may indicate that TGF-Ý1 induce the expression of COX-2
Cyclooxgynase-2 Factor-Ý1 Salivary gland