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Risk factors of non motor symptoms in parkinson disease /

Raed Mohamed Ali Mahmoud

Risk factors of non motor symptoms in parkinson disease / العوامل المؤثرة فى الأعراض غير الحركية فى مرض باركنسون Raed Mohamed Ali Mahmoud ; Supervised Omar Amin Mustafa Elserafy , Marwa Farghaly Ahmed Ibrahim , Shaimaa Shaheen Mohamed Abdelrazek - Cairo : Raed Mohamed Ali Mahmoud , 2021 - 112 , (30) P. : charts ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Neuropsychiatry

Background: Parkinsons disease (PD) is now recognized to comprise a wide range of motor and non-motor symptoms (NMS).These NMS could manifest many years before motor symptoms and to be predominant as the disease advances, thereby constituting a major source of disease burden for patients with Parkinsons disease. Objectives: to study risk factors of non- motor symptoms in PD and detect prevalence of non-motor symptoms in PD patients. Methods: 50 patients were recruited from Kasr Alainy hospital, movement disorder outpatient clinic.These patients clinical history data was collected and they were assessed for staging and severity of PD by the Movement Disorder Society (MDS)-UPDRS, Cognition by Montreal cognitive assessment scale (MOCA) test, Depression by Hamilton Depression Rating scale (HAM-D), Sleep disorder by Parkinsons disease sleep scale (PDSS) and for Apathy by Apathy scale (AS). Results: 98% of PD patient of our study affected at least by one of NMS, 76% had cognitive impairment, 76% had sleep disturbance, 68% had depression and 30% of patients had apathy. Disease severity was the most prominent risk factor for most of NMS, bradykinesia was risk factor for cognitive impairment while education was a protective factor for it. Conclusion: NMS is present in almost all of PD patients and related mainly by disease severity



Non-Motor symptoms Parkinson disease Risk Factors