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The role of absolute monocytic count in early diagnosisof necrotizing Enterocolitis in premature neonates /

Ahmed Fathi Ahmed Hussien

The role of absolute monocytic count in early diagnosisof necrotizing Enterocolitis in premature neonates / دور العد المطلق للخلايا الاحادية فى التشخيص المبكر لالتهاب الامعاء و القولون الناخر فى حديثى الولادة و المبتسرين Ahmed Fathi Ahmed Hussien ; Supervised Hebat Allah Hany Abouhussien , Dalia Mohamed Ahmed Helal , Moushira Hosny EzzeIarab Sayed - Cairo : Ahmed Fathi Ahmed Hussien , 2021 - 114 P. : charts , facsimiles ; 25cm

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Introduction: necrotizing enterocolitis (NEC) is characterized by macrophage infiltration in the intestine. As intestinal macrophages are derived from recruitment of blood monocytes into gut mucosa, it in turn reduces blood monocytes concentration which can be helpful marker for NEC. Aim of work: to estimate the role of absolute monocytic counts in differentiation between NEC from other causes of feeding intolerance in preterm. Patients and methods: This was a Prospective study which was conducted (after exclusion of 44 (25.1%) neonates after their death) for 131 neonates (70.2% with feeding intolerance and 29.8% with NEC). All the included preterms were subjected to full history taking, examination and investigations, in addition to level of AMC.Results: statistically significant difference between preterm with FI and preterm with NEC regards nutritional history with p-value <0.001 most of FI preterm was on trophic feeding while most of NEC preterm were on TPN. Statistically significant decrease of Ballard score in NEC preterm than feeding intolerance with p-value=0.014 as infants in feeding intolerance group developed feeding intolerance at an earlier postnatal age than those with NEC. AMC after 3-5 days after FI had statistically significant difference between NEC and FI with p-value < 0.05



Feeding intolerance NEC Preterm