Study of the Possible Role of Adenosine A2A Receptor In Modulating Experimentally Induced Mania in Rats / (Record no. 165170)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03046nam a2200277Ia 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 231030s9999 xx 000 0 und d |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposit |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 636.93233 |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.09.Ph.D.2022.He.S |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Heba Nasr Mohamed Moustafa |
| 245 ## - TITLE STATEMENT | |
| Title | Study of the Possible Role of Adenosine A2A Receptor In Modulating Experimentally Induced Mania in Rats / |
| Statement of responsibility, etc. | by Heba Nasr Mohamed Moustafa ؛ Under the supervision of Afaf Abdel-Moneim Ain-Shoka,Hala Fahmy Zaki,Reham Atef Mohamed |
| 246 ## - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة الدور المحتمل لمستقبل الأدينوسين أ2أ فى تطبيع الهوس المحدث تجريبيا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | 2022. |
| 336 ## - CONTENT TYPE | |
| Source | rda content |
| Content type term | text |
| 337 ## - MEDIA TYPE | |
| Source | rdamedia |
| Media type term | Unmediated |
| 338 ## - CARRIER TYPE | |
| Source | rdacarrier |
| Carrier type term | volume |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University,2022. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: p. 94-119. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Adenosinergic system dysfunction is implicated in the pathophysiology of multiple neuropsychiatric disorders including mania and bipolar disease. The established synergistic interaction between adenosine A2A (A2A) and dopamine (D2) receptors in the prefrontal cortex could highlight the idea of A2AR antagonism as a possible anti-manic strategy. Hence, the present study was performed to examine the effect of a selective A2AR blocker (SCH58261) on methylphenidate induced mania like behavior while investigating the underling mechanisms. Rats were injected with methylphenidate (5 mg/kg/day, i.p.) for three weeks with or without administration of either SCH58261 (0.01 mg/kg/day, i.p.) or lithium (150 mg/kg/day, i.p.) starting from day 9. In the diseased rats, A2AR antagonism reduced locomotor hyperactivity and risk-taking behavior along with decreased dopamine and glutamate levels. Meanwhile, SCH58261 restored N-methyl-D-aspartate receptor (NMDA) function, suppressed protein kinase C-alpha (PKC-α) expression, down-regulated β-Arrestin-2, up-regulated phosphorylated protein kinase B (pS473-Akt) and glycogen synthase kinase-3β (pS9-GSK-3β). Further, SCH58261 promoted synaptic plasticity markers through increasing brain derived neurotrophic factor (BDNF) level along with down-regulating growth-associated protein-43 (GAP-43) and synaptosomal associated protein-25 (SNAP-25). The A2A antagonist also reduced nuclear factor-kappa B p65 (NF-κBp65) and tumor necrosis factor-alpha (TNF-α) together with elevating interleukin-27 (IL-27) level giving an anti-inflammatory effect. In conclusion, suppression of PKC-α and modulation of Akt/GSK-3β/β-catenin axis through A2AR inhibition, could introduce A2AR as a possible therapeutic target for treatment of mania like behavior. This notion is supported by the ability of the A2AR antagonist (SCH58261) to produce comparable results to those observed with the standard anti-manic drug (lithium). |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rats as laboratory animals |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | prefrontal cortex |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reham Atef Mohamed |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Mohamady |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.09.Ph.D.2022.He.S | 01010110087276000 | 30.10.2023 | Thesis |