Estimation of the safety and antitumor activity of silver doped hydroxyapatite nanoparticles in mice / (Record no. 165719)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 07007namaa22004091i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240211192451.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 231119s2023 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 591.35 |
| Edition number | 21 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 591.35 |
| Edition number | 21 |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.21.M.Sc.2023.Re.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Maged Ahmed Sheta, |
| Relator term | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Estimation of the safety and antitumor activity of silver doped hydroxyapatite nanoparticles in mice / |
| Statement of responsibility, etc. | by Reem Maged Ahmed Sheta ; supervised by Ass. Prof. Hanan Ramadan Hamad, Prof. Gehan Safwat ElHusseiny. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | ﺗﻘدﯾر اﻟﺳﻼﻣﺔ واﻟﻧﺷﺎط اﻟﻣﺿﺎد ﻟﻠورم ﻣن ﺟزﯾﺋﺎت ھﯾدروﻛﺳﯾﺑﺎﺗﯾت اﻟﻧﺎﻧوﯾﺔ اﻟﻣطﻌﻣﺔ ﺑﺎﻟﻔﺿﺔ ﻓﻲ اﻟﻔﺋران |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 135 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rdacontent |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 119-131. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Currently, the main therapies for treating cancer are associated with a variety of side effects.<br/>Accordingly, researchers are focusing on the use of nanotherapy to develop a highly novel, less toxic<br/>and extremely efficient therapeutic agents for cancer treatment. Silver doped Hydroxyapatite<br/>nanoparticles (Ag:HAp-NPs) have shown effective at treating both infections and cancerous tumors<br/>while being non- cytotoxic to normal healthy cells in vitro. Therefore, this study was undertaken to<br/>estimate the safety and anti-tumor activity of silver doped hydroxyapatite nanoparticles in mice in<br/>vivo. Regarding the antitumor activity, concurrent administration of Ag:HAp-NPs caused a<br/>significant decrease in tumor volume and weight. Additionally, it showed a high elevation of<br/>intracellular ROS generation as well as MDA levels within tumor tissues and lead to the induction<br/>of DNA breaks. The high production of intracellular ROS generation, and the oxidative stress<br/>induction by Ag:HAp-NPs within tumor tissues confirmed a decrease in GSH and GPx levels.<br/>Significant elevation of P53 and HO-1 gene and decrease in Hsp70 and Kras was observed as well.<br/>Additionally, the percentage of necrotic tissue in tumor- induced groups and % of degenerated tumor<br/>cells after treatment with Ag:HAp-NPs were significantly elevated. Regarding the safety of Ag:HAp-<br/>NPs, it was shown to be safe and non-genotoxic. This was confirmed by the non-significant changes<br/>in TL and TM in the bone marrow and liver tissues. It was further confirmed by the observed non-<br/>significant changes in the MDA and TAC levels as well as the SOD activity in the liver among the<br/>safety groups, except for high dosage level. Moreover, histological examinations demonstrated that<br/>Silver doped Hydroxyapatite nanoparticles have mild toxicity on kidney and liver tissues with<br/>minimal inflammatory reactions associated with the presence of Ag:HAp-NPs in contrast with<br/>Cisplatin. In conclusion, silver doped hydroxyapatite nanoparticles have a potential anticancer<br/>activity against induced solid tumors in mice and demonstrated a higher level of safety for the liver,<br/>kidney and bone marrow tissues, making Ag:HAp-NPs a promising anti-tumor agent. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ﺣﺎﻟًﯿﺎ،ﺗﺮﺗﺒﻂ اﻟﻌﻼﺟﺎت اﻟﺮﺋﯿﺴﯿﺔ ﻟﻌﻼج اﻟﺴﺮطﺎن ﺑﻤﺠﻤﻮﻋﺔ ﻣﺘﻨﻮﻋﺔﻣﻦاﻵﺛﺎر اﻟﺠﺎﻧﺒﯿﺔ.وﻓًﻘﺎ ﻟﺬﻟﻚ،ﯾﺮﻛﺰا ﻟﺒﺎﺣﺜﻮن ﻋﻠﻰ<br/>اﺳﺘﺨﺪام اﻟﻌﻼج ﺑﺎﻟﻨﺎﻧﻮ ﻟﺘﻄﻮﯾﺮ ﻋﻮاﻣﻞ ﻋﻼﺟﯿﺔ ﺟﺪﯾﺪة ﻟﻠﻐﺎﯾﺔ ؤاﻗﻞ ﺳﻤﯿﺔ وﻓﻌﺎﻟﺔ ﻟﻠﻐﺎﯾﺔ ﻟﻌﻼج اﻟﺴﺮطﺎن.ٔاظﮭﺮت ﺟﺰﯾﺌﺎت<br/>ھﯿﺪروﻛﺴﯿﺒﺎﺗﯿﺖ اﻟﻨﺎﻧﻮﯾﺔ اﻟﻤﻄﻌﻤﺔ ﺑﺎﻟﻔﻀﺔ)Ag: HAp-NPs( ﻓﻌﺎﻟﯿﺘﮭﺎ ﻓﻲ ﻋﻼج ﻛﻞ ﻣﻦ اﻻﻟﺘﮭﺎﺑﺎت واﻷورام اﻟﺴﺮطﺎﻧﯿﺔ<br/>ﺑﯿﻨﻤﺎ ﺗﻜﻮن ﻏﯿﺮﺳﺎﻣﺔ ﻟﻠﺨﻼﯾﺎ اﻟﺴﻠﯿﻤﺔ ﻣﻌﻤﻠﯿﺎ in vitro .ﻟﺬﻟﻚ،ٔ اﺟﺮﯾﺖ ھﺬه اﻟﺪراﺳﺔ ﻟﺘﻘﺪﯾﺮ اﻟﺴﻼﻣﺔ واﻟﻨﺸﺎط اﻟﻤﻀﺎد ﻟﻠﻮرم<br/>ﻣﻦ ﻟﺠﺴﯿﻤﺎت ھﯿﺪروﻛﺴﯿﺒﺎﺗﯿﺖ اﻟﻨﺎﻧﻮﯾﺔ اﻟﻤﻄﻌﻤﺔ ﺑﺎﻟﻔﻀﺔ ﻓﻲ اﻟﻔﺌﺮان ﻓﻲ اﻟﺠﺴﻢ اﻟﺤﻲ in vivo .ﻓﯿﻤﺎ ﯾﺘﻌﻠﻖ ﺑﺎﻟﻨﺸﺎط اﻟﻤﻀﺎد<br/>ﻟﻠﻮرم، ﺗﺴﺒﺐ اﻹ ﻋﻄﺎء اﻟﻤﺘﺰاﻣﻦ ﻟـ Ag: HAp-NPs ﻓﻲ اﻧﺨﻔﺎض ﻛﺒﯿﺮ ﻓﻲ ﺣﺠﻢ ووزن اﻟﻮرم. ﺑﺎﻹﺿﺎﻓﺔٕ اﻟﻰ ذﻟﻚ اظﮭﺮ<br/>ارﺗﻔﺎﻋﺎ ﻛﺒیرا ﻓﻲﺗﻮﻟﯿﺪ ROSداﺧﻞ اﻟﺨﻼﯾﺎ وﻛﺬﻟﻚ ﻣﺴﺘﻮﯾﺎتMDA داﺧل أﻧﺴﺠﺔ اﻟﻮرم وﯾٔﻮديٕ اﻟﻰ ﺗﺤﺮﯾﺾ ﻓﻮاﺻﻞ<br/>اﻟﺤﻤﺾاﻟﻨﻮوي.ٔ اﻛﺪ اﻹﻧﺘﺎج اﻟﻌﺎﻟﻲﻟﺘﻮﻟﯿﺪ ROS داﺧﻞ اﻟﺨﻼﯾﺎ، وﺗﺤﺮﯾﺾ اﻹﺟﮭﺎد اﻟﺘﺄﻛﺴﺪي ﺑﻮاﺳﻄﺔ Ag: HAp-NPs<br/>داﺧﻞٔ اﻧﺴﺠﺔاﻟﻮرم اﻧﺨﻔﺎﺿا ﻓﻲ ﻣﺴﺘﻮﯾﺎت GSHو.GPxﻛﻤﺎ ﻟﻮﺣﻆ ارﺗﻔﺎع ﻛﺒﯿﺮ ﻓﻲ ﺟﯿﻦP53وHO-1واﻧﺨﻔﺎضﻓﻲ<br/>Hsp70وKras.ﺑﺎﻹﺿﺎﻓﺔٕ اﻟﻰذﻟﻚ،ﺗﻢ رﻓﻊ ﻧﺴﺒﺔ اﻷﻧﺴﺠﺔ اﻟﻤﯿﺘﺔ ﻓﻲ اﻟﻤﺠﻤﻮﻋﺎت اﻟﺘﻲ ﯾﺴﺒﺒﮭﺎ اﻟﻮرم وﻧﺴﺒﺔ اﻟﺨﻼﯾﺎ<br/>اﻟﺴﺮطﺎﻧﯿﺔاﻟﻤﺘﺪھﻮرةﺑﻌﺪاﻟﻌﻼج Ag: HAp-NPsﺑﺸﻜﻞﻣﻠﺤﻮظ.ﻓﯿﻤﺎﯾﺘﻌﻠﻖﺑﺴﻼﻣﺔ :Ag HAp-NPs،ﻓﻘﺪﺛﺒﺖٔ اﻧﮭﺎ<br/>ٓاﻣﻨﺔوﻏﯿﺮﺳﺎﻣﺔﻟﻠﺠﯿﻨﺎت.ﺗﻢﺗﺄﻛﯿﺪذﻟﻚﻣﻦﺧﻼل اﻟﺘﻐﯿﯿﺮات ﻏﯿﺮاﻟﻤﮭﻤﺔﻓﻲTLوTMﻓﻲﻧﺨﺎع اﻟﻌﻈﺎم ؤاﻧﺴﺠﺔاﻟﻜﺒﺪ.ﺗﻢ<br/>ﺗﺄﻛﯿﺪذﻟﻚٔای ًﺿﺎﻣﻦ ﺧﻼل اﻟﺘﻐﯿﯿﺮات ﻏﯿﺮاﻟﻤﻠﺤﻮظﺔ ﻓﻲﻣﺴﺘﻮﯾﺎت MDAوTACﺑﺎﻹﺿﺎﻓﺔٕ اﻟﻰﻧﺸﺎطSODﻓﻲاﻟﻜﺒﺪ |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Text in English and abstract in Arabic & English. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Genetics |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Silver doped hydroxyapatite |
| -- | cancer |
| -- | mice |
| -- | antitumor |
| -- | oxidative stress and safety |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Ramadan Hamad, |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gehan Safwat El Husseiny, |
| Relator term | thesis advisor. |
| 900 ## - EQUIVALENCE OR CROSS-REFERENCE-PERSONAL NAME [LOCAL, CANADA] | |
| Numeration | 28-09-2023 |
| Titles and other words associated with a name | Hanan Ramadan Hamad |
| -- | Gehan Safwat El Husseiny |
| Dates associated with a name | Ahmed Emam Dakroury |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Divisons | Department of Zoology |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Hanan |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | Not for loan | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.21.M.Sc.2023.Re.E | 01010110087728000 | 19.11.2023 | Thesis |