Assessment of biventrecular Strain using feature tracking Cardiac mr (ft-cmr) in pre- Capillary pulmonary Hypertension / (Record no. 167435)
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| 000 -LEADER | |
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| fixed length control field | 10748namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033247.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240610s2020 |||a|||f |m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| Language code of sung or spoken text | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.07548 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.077548 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01 11 31 Ph.D 2020 Ma.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Marwa Mohammed Naguib, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Assessment of biventrecular Strain using feature tracking Cardiac mr (ft-cmr) in pre- Capillary pulmonary Hypertension / |
| Statement of responsibility, etc. | By Marwa Mohammed Naguib; Under Supervision of Prof. Noha Hossam El Din Behairy, Prof. Mostafa Ali Ibrahem El Shazly, Prof. Samira El-Sayed Saraya, Dr. Wesam Emaam El Mozyز |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم سلاسة البطينين باستخدام تتبع خواص الرنين المغناطيسي للقلب لمرضى ارتفاع ضغط الشريان الرئوي ما قبل الشعيرات الدموية / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2020. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 110 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2020. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 98-108. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Pulmonary Hypertension (PH) is a life-threatening <br/>disease that affects the pulmonary arteries, which are the vessels <br/>responsible for carrying blood from the heart to the lungs. The disease is <br/>characterized by high blood pressure in the lungs, as well as narrowed and <br/>blocked arteries and capillaries. It is a disease that generally gets worse <br/>over time and may even result in death. There is currently no cure for <br/>pulmonary hypertension, but there are treatments that can help improve <br/>patients’ quality of life and reduce symptoms. It is known that pulmonary <br/>hypertension is closely associated with heart failure. RV and left <br/>ventricular (LV) function and volumes were found to be powerful <br/>predictors of prognosis and treatment response, thus early detection of <br/>myocardial deformation abnormality and systolic impairment is of utmost <br/>importance. Cardiac magnetic resonance feature tracking (CMR FT) is a <br/>novel efficient noninvasive tool for myocardial strain quantification that <br/>may allow detection of early myocardial abnormalities using routinely <br/>acquired cine images. <br/>Purpose <br/>To determine the value of RV and LV strain analysis by FT as a diagnostic <br/>tool in PHT patients <br/>Methods <br/>Study population <br/>CMR exams were performed on a 1.5T machine to assess RV and LV <br/>volumes and function, this study included 40 patients with PH 17 males <br/>and 23 females divided into 16 patients with chronic thromboembolic <br/>pulmonary hypertension(CTEPH) and 24 patients with pulmonary <br/>hypertension(PAH), with a mean age of 33.5 years (range = 17 – 59). Mean <br/>RV EF was 32.7 ± 12.9%. Mean LV EF was 59.9 ± 9.5% <br/>CMR exams of a control group of 40 healthy volunteers, 21 males and 19 <br/>females, with a mean age of 24 years (range = 17 – 57) were involved. <br/>Mean RV EF was 59.4 ± 6.9% Mean LV EF was 60.8 ± 6.1%. <br/>Magnetic resonance imaging studies were performed with balanced steady <br/>state free precession (b.SSFB) using a 1.5 T MRI scanner (Seimens <br/>Magnetom Aera, Seimens Medical Systems, Eriangen, Germany) and <br/>segment medical analysis CMR software performing strain analysis <br/>(FTCMR) of the right and left ventricles. Long axis standard steady-state <br/>in free-precession (SSFP) cine images were used for longitudinal, <br/>circumferential and global strain quantification in both groups using CMR <br/>FT. Results of the strain values of both groups were compared and <br/>correlated with RV and LV CMR derived EFs and cardiac mass. <br/>Inclusion criteria: <br/> Patients diagnosed with precapillary pulmonary hypertension by right <br/>heart catheterization (RHC). <br/> Controls. <br/>Exclusion criteria: <br/> Patients diagnosed with postcapillary pulmonary hypertension. <br/>Results: <br/>40 patients divided to 16 (CTPEH), 24 (PH) and 40 controls. <br/>LV EF (ejection fraction) was quite similar in patients group (59.9 ± 9.5%) <br/>and control group (60.8 ± 6.1%), p=0.60. Indexed LV mass (gm/m2) was <br/>not significantly different in patients group compared to control group 45.5 <br/>(35.0, 54.8) versus 47.9 (41.6, 52.4) respectively (P=0.40), RV EF <br/>(ejection fraction) differs greatly in patients group compared to control <br/>group (32.7 ± 12.9%) versus (59.4 ± 6.9%) respectively (P <0.001), LV <br/>GLS (%) (Global longitudinal strain) show a big difference too in patients <br/>group compared to controls group -13.5 (-14.9, -11.7) versus -17.7 (-18.9, <br/>-16.7) respectively (P<0.001), LV peak circumferential strain show no <br/>significantly difference in patients group compared to control group, -17.0 <br/>± 4.8% versus -18.7 ± 5.5% respectively (p=0.16). LV radial strain differs <br/>significantly in patients group compared to control group (25.6 ± 9.5%) <br/>versus (29.6 ± 10.0%) (P= 0.07) The greatest difference in strain was seen <br/>in RV GLS (-10.4 ± 3.3%) in patients group versus (-23.0 ± 2.9%) in <br/>control group (p<0.001) which is statistically significantly impaired, as <br/>well as RV global strain rate - upslope 20.6 (15.1, 32.4) in patients group <br/>versus 69.7 (56.5, 79.0) in control group (p<0.001), and RV global strain <br/>rate – downslope (-37.1 ± 12.6) in patients group versus (-82.6 ± 11.4) in <br/>controls group (p<0.001). <br/>The two groups of (CTPEH) and (PAH) patients show a significant <br/>difference in the cardiac mass [in (CTEPH) 51.0 (40.0, 55.0) versus in <br/>(PAH) 41.0 (33.5, 54.5), (P= 0.099)] and in PVR (Woods units) [in <br/>(CTEPH) 14.5 (12.0, 18.8) versus (PAH) 19.0 (13.3, 21.0) (P= 0.04)]. <br/>Conclusions: <br/>CMR-Feature Tracking strain analysis is a powerful tool that can add a <br/>diagnostic value in patients with pulmonary hypertension. It is able to <br/>detect LV & RV wall deformation abnormalities efficiently and <br/>objectively, evidenced by EF It is also can correlates with disease severity, <br/>and independently associated with poor outcomes in PH. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | الخلفية: ارتفاع ضغط الدم الرئوي (PH) هو مرض يهدد الحياة ويصيب الشرايين الرئوية ، وهي الأوعية المسؤولة عن نقل الدم من القلب إلى الرئتين. ويتميز المرض بارتفاع ضغط الدم في الرئتين ، وكذلك تضيق وانسداد الشرايين والشعيرات الدموية. إنه مرض يزداد سوءًا بشكل عام بمرور الوقت وقد يؤدي إلى الوفاة. لا يوجد حاليًا علاج لارتفاع ضغط الدم الرئوي ، ولكن هناك علاجات يمكن أن تساعد في تحسين نوعية حياة المرضى وتقليل الأعراض. من المعروف أن ارتفاع ضغط الدم الرئوي يرتبط ارتباطًا وثيقًا بفشل القلب. تم العثور على وظائف وأحجام البطين الأيسر والبطين الأيسر (LV) لتكون منبئات قوية للتنبؤ والاستجابة للعلاج ، وبالتالي فإن الكشف المبكر عن تشوه عضلة القلب والضعف الانقباضي له أهمية قصوى. تتبع ميزة الرنين المغناطيسي للقلب (CMR FT) هي أداة جديدة فعالة غير باضعة لتقدير إجهاد عضلة القلب والتي قد تسمح باكتشاف تشوهات عضلة القلب المبكرة باستخدام الصور السينمائية المكتسبة بشكل روتيني.<br/>غاية<br/>لتحديد قيمة تحليل الإجهاد RV و LV بواسطة FT كأداة تشخيصية في مرضى PHT<br/>طُرق<br/>دراسة السكان<br/>تم إجراء فحوصات CMR على جهاز 1.5T لتقييم أحجام ووظائف RV و LV ، وشملت هذه الدراسة 40 مريضًا مع PH 17 ذكور و 23 إناث مقسمة إلى 16 مريضًا يعانون من ارتفاع ضغط الدم الرئوي المزمن الانصمام الخثاري (CTEPH) و 24 مريضًا يعانون من ارتفاع ضغط الدم الرئوي (PAH) ) بمتوسط عمر 33.5 سنة (المدى = 17-59). كان متوسط RV EF 32.7 ± 12.9٪. كان متوسط LV EF 59.9 ± 9.5٪<br/>تم إجراء اختبارات CMR لمجموعة تحكم مكونة من 40 متطوعًا سليمًا ، 21 ذكرًا و 19 أنثى ، بمتوسط عمر 24 عامًا (النطاق = 17-57). كان متوسط RV EF 59.4 ± 6.9٪ وكان متوسط LV EF 60.8 ± 6.1٪.<br/>تم إجراء دراسات التصوير بالرنين المغناطيسي بمبادرة متوازنة ثابتة وخالية من الحالة (b.SSFB) باستخدام ماسح ضوئي 1.5 T MRI (Seimens Magnetom Aera ، Seimens Medical Systems ، Eriangen ، ألمانيا) وقسم برنامج التحليل الطبي CMR الذي يقوم بإجراء تحليل الإجهاد (FTCMR) من البطين الأيمن والأيسر. تم استخدام صور سينمائية ثابتة ذات محور طويل في صور سينمائية بدائية حرة (SSFP) لتقدير الإجهاد الطولي والقطري والعالمي في كلا المجموعتين باستخدام CMR FT. تمت مقارنة نتائج قيم الانفعال لكلا المجموعتين وربطها بمؤثرات ضغط كهربائية مشتقة من RV و LV CMR وكتلة القلب.<br/>معايير الاشتمال:<br/>• المرضى الذين تم تشخيص إصابتهم بارتفاع ضغط الدم الرئوي قبل الشعيرات الدموية عن طريق قسطرة القلب الأيمن (RHC).<br/> • ضوابط.<br/>معايير الاستبعاد:<br/>• المرضى الذين تم تشخيص إصابتهم بارتفاع ضغط الدم الرئوي بعد الشعيرات الدموية.<br/>نتائج:<br/>40 مريضا مقسمة إلى 16 (CTPEH) و 24 (PH) و 40 ضابطا. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Radio-diagnosis |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | CMR-FT, RV |
| -- | RVEF, LV GLS |
| -- | RV GLS |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Hossam El Din Behairy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Ali Ibrahem El Shazly |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samira El-Sayed Saraya |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Wesam Emaam El Mozy |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2020 |
| Supervisory body | Noha Hossam El Din Behairy |
| -- | Mostafa Ali Ibrahem El Shazly |
| -- | Samira El-Sayed Saraya |
| -- | Wesam Emaam El Mozy |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Radio-diagnosis |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Nourhan |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 10.06.2024 | 88405 | Cai01 11 31 Ph.D 2020 Ma.A | 01010110088405000 | 10.06.2024 | 10.06.2024 | Thesis |