Structural and vascular density affection of macular and peripapillary areas in patients having multiple sclerosis vs neuromyelitis optica with previous optic neuritis / (Record no. 168405)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 10984nam a22004337i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20241022101617.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241014s2023 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 617.71 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 617.71 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.24.Ph.D.2023.Fa.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Fatma Khaled Abd El-Kareem Hassan, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Structural and vascular density affection of macular and peripapillary areas in patients having multiple sclerosis vs neuromyelitis optica with previous optic neuritis / |
| Statement of responsibility, etc. | by Fatma Khaled Abd El-Kareem Hassan ; Supervision of Prof. Dr. Hatem Ahmed Hassan Saeed , Prof. Dr. Mai Mohamed Helmy Shaarawy , Prof. Dr. Nirmeen Adel Kishk , Dr. Ayman Gehad Adel ELNahry. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | / تأثر هيكلة وكثافة الأوعية الدموية في الماقولة وحول العصب البصري في مرضى التصلب المتعدد مقابل اضطرابات طيف التهاب النخاع والعصب البصري في وجود التهاب سابق بالعصب البصري |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 194 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 150-180. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: Comparing the peripapillary and the macular vascular density changes in NMOSD and MS patients with previous history of optic neuritis using the OCTA and measuring the thickness of the RNFL and the ganglion cell complex using the SD- OCT .Also, finding a correlation between the loss in the retinal nerve fiber layer and the ganglion cell layer measured by OCT with the vascular density measured by OCTA in patients visiting the Kasr Alainy Multiple Sclerosis Unit (KAMSU) and ophthalmology clinics of Cairo University Hospitals<br/>Study Design: An Observational Cross Sectional Comparative Study.<br/>Methods: 20 eyes of 13 MS patients and 20 eyes of 12 NMOSD patients who had previous attacks of optic neuritis recruited from Kasr Alainy Multiple Sclerosis Unit (KAMSU) and ophthalmology outpatient clinics in Cairo university hospitals were compared with 20 eyes of healthy normal controls regarding their demographic data, clinical and visual assessment, and evaluation of their OCTA and SD-OCT parameters.<br/>Results: The best-corrected visual acuity, the SDMT score and the disc appearance were statistically significant different between the MS group and the control group with p-values 0.005,0.003 and 0.000 respectively and between the NMOSD group and our control group with p-values 0.004,0.000, and 0.000 respectively. Also, significant differences were detected regarding the age, disease duration and the EDSS between the MS and the NMOSD group with p-values 0.000 and 0.001 respectively.<br/>Using OCTA, no significant differences were detected in the choricapillaries flow area and the foveal avascular zone area (FAZ) between MS, NMOSD, and control groups. Statistically significant differences were found in foveal density and central macular thickness of the DVP between the MS and NMOSD groups (p- values=0.023, and 0.013 respectively), and between the NMOSD and control groups with p-values=0.003, and 0.003 respectively regarding the same parameters. Statistically significant differences were also found between MS and NMOSD groups in the SVP parameters (WI, foveal density, parafoveal superior hemi, and perifovea) with p-values=0.021,0.013,0.048, and 0.020 respectively, and statistically significant differences were detected between MS and NMOSD groups in RPC density% parameters (WI, total peripapillary, peripapillary superior hemi, and peripapillary inferior hemi) with p-values=0.016,0.016,0.008, and 0.040 respectively.<br/>Using the SD-OCT, highly statistically significant differences were detected between MS and NMOSD groups in RNFL thickness (average, superior, and inferior) with p-values 0.003,0.001, and 0.020 respectively, and also in ganglion cell complex GCC thickness (average, and superior) with p-values 0.032, and 0.020 respectively.<br/>In MS group, significant correlations were found between their BCVA (LogMAR) and their EDSS, and between their BCVA(LogMAR)and DVP parameters (WI, parafoveal density, parafoveal superior hemi, parafoveal inferior hemi, and<br/> <br/>perifovea), and foveal density of the SVP. Strong positive correlations were detected between their RNFL (average, superior, and inferior) and their choriocapillaries flow area, most of the SVP density parameters, and most of the RPC density<br/>%parameters, and also strong positive correlations were reported between their GCC (average, superior, and inferior) and most of the SVP density parameters, and the whole image of RPC density % in the same group.<br/>While, in NMOSD group, the BCVA(LogMAR) was correlated with duration, number of eye attacks, central macular thickness of the DVP, RPC density %(the WI, total peripapillary, and peripapillary inferior hemi), all RNFL, and all GCC parameters. Strong positive correlations were detected between their RNFL (average, superior, and inferior) and most of the SVP density parameters and most of the RPC density % parameters,and between their GCC (average, superior, and inferior) and central macular thickness of the DVP,and most of the SVP density parameters and most of the RPC density % parameters.<br/>Conclusion: Our study concluded that EDSS may be a useful adjunct for differentiation between NMOSD and MS patients who developed previous optic neuritis., as the best cutoff point for EDSS to detect NMOSD cases was found to be<br/>>2, with a sensitivity of 91.67%, a specificity of 69.23%, and an area under the curve (AUC) of 86.5%.Also,combining OCTA and OCT parameters aid us in distinguishing both diseases, with further studies on a large scale should be warranted as early diagnosis of NMOSD will have the potential to decrease future disability. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | من المهم التشخيص المبكر والدقيق لمرضي طيف التهاب النخاع والعصب البصرى والتفرقة بين هذا المرض ومرض التصلب المتعدد حيث وجد ان مرض طيف التهاب النخاع والعصب البصرى كان أكثر شراسة ويحتاج الي علاج معين ومختلف ولذلك في هذه الدراسة قمنا باستخدام الماسح الضوئي المترابط والتصوير المقطعي المترابط للأوعية الدقيقة في هؤلاء المرضي بعد حدوث التهاب سابق لهم بالعصب البصري لدراسة التغيرات الهيكلية والتغيرات الدقيقة بالأوعية الدموية ومقاراناتهم بالأصحاء.<br/>في هذه الدراسة المقارنة المقطعية العشوائية تم اختبار 20 عين من 13 مريض بالتصلب المتعدد و20 عين من 12 مريض باضطراب طيف التهاب النخاع والعصب البصري من المترددين علي وحدة التصلب المتعدد بالقصر العيني والعيادات الخارجية بمستشفيات جامعة القاهرة ومقارنتهم ب 20 عين من الأصحاء فيما يتعلق ببياناتهم الديموغرافية والفحص الاكلينيكي وقياسات التصوير المقطعي المترابط للاوعية الدموية الدقيقة وأيضا قياسات الماسح الضوئي المترابط. <br/>وقد كان التأثر واضحا فيما يخص حدة الابصار بين مرضي التصلب المتعدد مقارنة بالأصحاء وكذلك بين مرضى طيف التهاب النخاع والعصب البصرى والاصحاء وقد وجدنا أيضا فروقا ذات دلالات احصائية فيما يخص قياس نسبة الاعاقة من المرض بين مرضي التصلب المتعدد ومرضي اضطراب طيف التهاب النخاع والعصب البصري.<br/>لم نجد أي اختلاف بين المجموعات الثلاثة فيما يخص الطبقة المشيمية الشعيرية والمنطقة اللاوعائية النقرية باستخدام التصوير المقطعي المترابط للأوعية الدموية. <br/>وقد وجدنا فروق ذات دلالات احصائية بين مرضي التصلب المتعدد ومرضي طيف التهاب النخاع والعصب البصرى وأيضا بين مرضي طيف التهاب النخاع والعصب البصرى وبين الاصحاء في كثافة الاوعية الدموية النقرية وسمك البقعة المركزية بالطبقة العميقة لشبكة الأوعية الدموية المحيطة بالماقولة.<br/>وأيضا كان هناك فروقا ذات دلالات احصائية واضحة بين مرضي التصلب المتعدد ومرضي طيف التهاب النخاع والعصب البصرى في كل قياسات سمك طبقة الألياف العصبية وسمك طبقة خلايا الكتلة العصبية المجمعة باستخدام الماسح الضوئي المترابط.<br/>وفي كل مرض علي حدة كانت هناك علاقة موجبة بين تدهورالقياسات الهيكلية والوظيفية ومعظم قياسات الطبقة السطحية لشبكة الاوعية الدموية المحيطة بالماقولة.<br/>وقد كانت قياس نسبة الاعاقة من المرض الأكثر قدرة علي اكتشاف وتحديد جميع الأشخاص المصابون بمرض طيف التهاب النخاع والعصب البصرى من بين المجموعات.<br/>ونستنتج من هذا أن مرض طيف التهاب النخاع والعصب البصرى يؤدي إلى إعتلال وتدهور القياسات الهيكلية والوظيفية للمريض مقارنة بمرض التصلب المتعدد لذلك ينبغي دراسة التغيرات الهيكلية والوظيفية علي أعداد أكبر من المرضي المصابون. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Ophthalmology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | MS |
| -- | NMOSD |
| -- | ON |
| -- | SVP |
| -- | DVP |
| -- | RPC density% |
| -- | SD-OCT |
| -- | OCTA |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hatem Ahmed Hassan Saeed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mai Mohamed Helmy Shaarawy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nirmeen Adel Kishk |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Gehad Adel ELNahry |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Hatem Ahmed Hassan Saeed |
| -- | Mai Mohamed Helmy Shaarawy |
| -- | Nirmeen Adel Kishk |
| -- | Ayman Gehad Adel ELNahry |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Ophthalmology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 14.10.2024 | 88766 | Cai01.11.24.Ph.D.2023.Fa.S | 01010110088766000 | 14.10.2024 | 14.10.2024 | Thesis |