The possible protective effect of Rosuvastatin on colistin-induced nephrotoxicity in rats / (Record no. 168767)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06769namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033322.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241111b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.9 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.9 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.M.Sc.2023.Ma.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Marihan Samir Shafik, |
| Preparation | preparation. |
| 245 14 - TITLE STATEMENT | |
| Title | The possible protective effect of Rosuvastatin on colistin-induced nephrotoxicity in rats / |
| Statement of responsibility, etc. | by Marihan Samir Shafik ; supervision of Dr. Amina Salem Attia , Dr. Dalia Moustafa El-Tanbouly , Dr. Abeer Mokhtar Bishr. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | / الفاعلية الوقائية الممكنة لدواء روسوفاستاتن في تسمم الكلى المستحدث بالكوليستين في الجرذان |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 120 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 95-103. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: Colistin-induced nephrotoxicity is associated with diminished activity of nuclear factor erythroid 2-related factor 2 (Nrf2), which is largely correlated with decreased microRNA-205 (miR-205) and increased cellular PH domain and leucine-rich repeat protein phosphatase (PHLPP2) levels. This study investigated the possible modulation of miR-205 and its downstream target, Egl-9 family hypoxia-inducible factor 2 (EGLN2) along with PHLPP2/ protein kinase B (Akt) trajectory as key regulators of Nrf2 stability by rosuvastatin to combat oxidative and endoplasmic reticulum (ER) stresses as pivotal contributors to colistin- associated renal injury.<br/>Methods: Rats were randomly divided into four groups; normal, colistin (300 000 IU/Kg/day; i.p), colistin pretreated with rosuvastatin (10 mg/kg; p.o) and colistin pretreated with rosuvastatin (20 mg/kg; p.o) for 6 successive days.<br/>Key findings: Pretreatment with rosuvastatin attenuated renal injury induced by colistin and enhanced kidney functions with a marked reduction in renal injury markers. Besides, rosuvastatin upregulated renal miR-205 expression and suppressed gene expression of EGLN2. In addition, it downregulated ER stress- related genes, activation transcription factor 4 (ATF4) and C/EBP homologous protein (CHOP) along with caspases 12 and 3. Meanwhile, rosuvastatin was effective in decreasing the mRNA expression of PHLPP2 to promote Akt phosphorylation. Consequently, it deactivated Glycogen synthase kinase-3 beta (GSK-3β) and reduced the gene expression of protein kinase Fyn (Fyn kinase) in renal tissues. Rosuvastatin’s modulatory effect on the two trajectories induced the expression and the nuclear translocation of Nrf2 as detected by immunohistochemical examination to boost the renal antioxidants, superoxide<br/><br/><br/>a<br/> <br/><br/>dismutase (SOD) and reduced glutathione (GSH). Accordingly, rats treated with rosuvastatin showed a great restoration of normal histological features.<br/>Conclusions: The present study demonstrates that rosuvastatin triggered a series of protective mechanisms against colistin-induced nephrotoxicity through modulating miR-205 and EGLN2 expression. It’s suppressive effect on both ATF4/ CHOP as well as PHLPP2 / Akt / GSK3 β / Fyn kinase trajectories endorsed Nrf2 activity to substantiate its antioxidant and anti-apoptotic capacities. Accordingly, it retrieved normal renal function and structure and prevented further renal disease progression and development into chronic kidney disease (CKD). |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ينتمي كوليستين إلى فئة المضادات الحيوية متعددة بولي ببتيد المعروفة باسم بوليمكسينات والتي أظهرت فعالية كبيرة ضد العدوى الناتجة من البكتيريا سالبة الجرام المقاومة لمضادات حيوية متعددة. ومع ذلك، أقتصر استخدامه السريري على المرضى في المستشفيات الذين يعانون من التهابات الرئوية المميتة وذلك بسبب آثاره الجانبية السامة علي الكلى. وترجع السمية الكلوية للكوليستين على وجود حمض د-أمينوبوتيريك وبعض الأحماض الدهنية التي تزيد من امتصاصه من قبل الأنابيب الكلوية، كما أن تركيبه الكيميائي يعيق انتشاره عبر غشاء البلازما مما يؤدي الى تراكمه في خلايا الأنابيب الكلوية ومن ثم إلى تنشيط الموت المبرمج للخلايا المعتمد على تنشيط الكاسبيز استجابة للإجهاد التأكسدي واجهادات الشبكة الاندوبلازمية. وبالتالي، هناك حاجة ملِحة إلى إيجاد دواء للتخفيف من الإصابة الكلوية الحادة الناجمة عن الكوليستين بحيث يمكن استخدامه بشكل آمن كمضاد حيوي للحالات العاجلة. <br/><br/> يعد روسوفاستاتين من أكثر الأدوية استخداما من عائلة الستاتين. وأثبت أن روسوفاستاتين له قدرة وقائية ضد القصور الكلوي الحاد الناجم عن الأدوية مثل الأمينوغليكوزيدات والأميكاسين. كما أظهر روسوفاستاتين مع سيمفاستاتين تأثير وقائي ضد السمية الكلوية الحادة الناجمة عن سيسبلاتين. وقد ظهرت قدرات روسوفاستاتين كمضاد للأكسدة ومضاد للالتهابات بوضوح من خلال حمايته ضد قصور الكبد والكلى الناجم عن بعض الأدوية مثل فيبرونيل وبيروكسيكام. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Toxicology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colistin |
| -- | Endoplasmic reticulum stress |
| -- | MiR-205, Nrf2 |
| -- | oxidative stress |
| -- | PHLPP2 |
| -- | Rosuvastatin |
| -- | Endoplasmic reticulum stress |
| -- | MiR-205 |
| -- | Nrf2 |
| -- | oxidative stress |
| -- | PHLPP2 |
| -- | Rosuvastatin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amina Salem Attia |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Moustafa El-Tanbouly |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abeer Mokhtar Bishr |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Amina Salem Attia |
| -- | Dalia Moustafa El-Tanbouly |
| -- | Abeer Mokhtar Bishr |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology and Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.11.2024 | 89188 | Cai01.08.09.M.Sc.2023.Ma.P | 01010110089188000 | 11.11.2024 | 11.11.2024 | Thesis |