Evaluation of chemo-preventive effect of black raspberries extract on oral squamous cell carcinoma cell line : (Record no. 169053)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05972nam a22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033331.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241125s2018 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposite |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 617.634 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 617.634 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.09.14.M.Sc.2018.Ha.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Hatem Mahmoud Ali Mahmoud, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of chemo-preventive effect of black raspberries extract on oral squamous cell carcinoma cell line : |
| Remainder of title | in vitro study / |
| Statement of responsibility, etc. | by Hatem Mahmoud Ali Mahmoud ; Supervisors Dr.Dina Soliman khater, Dr.Sara Mohammed Abd El Wahed. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | : تقييم الأثر الوقائى الكيميائى لمستخلص التوت الأسود على خط الخلايا السرطانية الحرشفية بالفم |
| Remainder of title | / دراسة مختبرية |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2018. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 93 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2018. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 75-90. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Aim: The aim of this study was to evaluate the anti-cancer effect of different concentrations of BR extract on oral squamous cell carcinoma cell line and compare between the effect of BR extract and the effect of<br/> Doxorubicin.Methodology: The human tongue squamous cell carcinoma cell line (SCC 15) was sub-cultured to obtain three groups, first group was treated with BR, second group treated with Doxorubicin and the third group was left untreated and used as a control group. The cells of the first two groups treated with BR and Doxorubicin at various concentrations (0.1, 1.0, 10, 100, 1000µg/ml) for 24,48and72hrs.<br/>Then MTT viability assay was measured in each group at the three time intervals, after that cell cycle analysis and apoptosis analysis were assessed using flowcytometry.Then, ELISA was done to measure caspase-3 as an apoptotic indicator at the same time intervalsResults: The cell viability percent showed a gradual decrease with increasing doses of the proposed treatments (BR and Dox). The values at 24h , 48h and 72h<br/>Statistical analysis revealed non-significant statistical differences on comparing the viability % of OSCC cells treated with Dox and BR among the three time intervals.<br/> Conclusions: BR has a potential cytotoxic effect on OSCC cell line in a dose- and time-dependent manner.<br/>BR show promising effects in the treatment and prevention of OSCC by inhibiting cell proliferation and induction of apoptosis with least side effects.<br/> There is a slight difference between the anticancer effect of BR and<br/>Dox which is a potent chemotherapeutic drug |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | يعتبر سرطان الخلايا الحرشفية بالفم اكثر انواع السرطان شيوعا,ونسبته فى تزايد مستمر.يعتبر العلاج الكيميائى و الجراحى هو العلاج الزئيسى المستخدم فى علاجه و لكن يعض المرضى يعانون الكثير من الاثار الجانبية الناتجة عنه ولهذا السبب يستمر العلماء فى البحث لاكتشاف عقار كيميائى جديد ذات اثار جانبية اقل. <br/>فى هذه الايام يوجه الباحثون اهتمامهم الى المكونات الطبيعية فى الخضروات و الفاكهة ومن اكثر الانواع بحثا هو التوت الاسود فهو يعتبر واحد من اقوى المواد التى تم دراسة تاثيراته كمضاد للاكسدة و مضاد للالتهابات و تنسب اثاره النافعة لما يحتويه من المزيج الفريد من الفلافينويد,الانثوثيانين وحمضالالاجيك اللذين يعتبرواالمكونات الاساسية المسؤلة عن الخصائص البيولوجية فى التوت الاسود. <br/>تلعب دورة الخلية وموت الخلايا المبرمج دور هام فى الوقاية من السرطان.ان للتوت الاسود تاثير فعال فى اقاف دورة الخلية فى مراحلها المختلفة ولذلك هو يمنع تكاثر الخلايا السرطانية بالاضافة الى زيادته الملحوظة فى عملية موت الخلايا المبرمج. <br/>نتائج اختبار المطهر اوضحت انقاص ملحوظ فى عدد الخلايا السرطانية ونقص ملحوظ فى نسبة 0IC5.بخصوص التدفق الخلوى,ان التوت الاسود اظهرنقص فى الخلايا السرطانية فى الثلاث مراحل الاساسية لدورة الخلية(G1,S and G2M) و نهائيا,اظهر اختبار ELISAنقص ملحوظ فى معدل كاسبيس-3 مما يشيرالى تنشيط عملية موت الخلايا المبرمج. <br/>و فى الختام,ان التوت الاسود مادة قوية كمضاد للتكاثرومضاد لعملية مت الخلايا المبرمج وعندما يستخدم مع العلاج الكيميائى سيكون هناك نقص مفيد فى حدوث سرطان الفم وسوف يعطى نتائج افضل. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Dental diseases |
| Source of heading or term | qrmak |
| 653 ## - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | carcinoma |
| -- | BR extract |
| -- | Doxorubicin |
| -- | Raspberries |
| -- | caspase-3 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Soliman khater |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sara Mohammed Abd El Wahed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2018 |
| Supervisory body | Dina Soliman Khater |
| -- | Sara Mohammed Abd El Wahed |
| Discussion body | Dalia Al Rouby |
| -- | Salah Hamed |
| Universities | Cairo University |
| Faculties | Faculty of Oral and Dental Medicine |
| Department | Department of Oral and Maxillofacial Pathology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 25.11.2024 | 89332 | Cai01.09.14.M.Sc.2018.Ha.E | 01010110089332000 | 25.11.2024 | 25.11.2024 | Thesis |