MARC details
| 000 -LEADER |
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| fixed length control field |
07019namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - أخر تعامل مع التسجيلة |
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| control field |
20250223033340.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
241207s2023 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloguing agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
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| Acquisition Source |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
615.6 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
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| Classification number |
615.6 |
| Edition number |
21 |
| 097 ## - Degree |
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| Degree |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Local Call Number |
Cai01.08.08.M.Sc.2023.Ra.L |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Authority record control number or standard number |
Rana Essam Mohamed Elnady, |
| Preparation |
preparation. |
| 245 10 - TITLE STATEMENT |
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| Title |
Lipid- based drug delivery system to improve the oral bioavailability of a certain drug : |
| Remainder of title |
antituberculosis / |
| Statement of responsibility, etc. |
by Rana Essam Mohamed Elnady ; Supervision of Prof. Dr. Maha Mohamed Amin, Prof. Dr. Mohamed Yehia Zakaria. |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
/ أنظمة توصيل دهنية لتحسين الإتاحة الحيوية لعقار مضاد للدرن عن طريق الفم |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
2023. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
(80) Leaves + Multiple numbering : |
| Other physical details |
illustrations ; |
| Dimensions |
30 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
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| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (M.Sc)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography: pages 60-61. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Tuberculosis (TB) is a serious disease that usually affects the lungs moreover, it can affect other organs infected with Mycobacterium. The management of TB is difficult due to frequent administration of antibiotic and developed drug resistance. Phytomedicinal drugs have confirmed their anti-mycobacterium efficacy in overcoming antibiotic problems, unfortianatly, they suffer from low solubility and bioavailability. Currently, the employment of emulsomes (EMLs) for antimicrobial drugs is a very attractive approach as a result of their capabilities to enclose both hydrophilic and lipophilic drugs, reach bacterial cells and disrupt their function, improve oral permeability, sustain drug release, increase drug stability and boost bioavailability. Many in vitro studies assist in the prediction of the suitability and efficacy of the formulated nanocarriers. <br/>The goal of this thesis was to obtain and optimize Naringenin (NAR)-loaded emulsomes (EMLs) aiming to boost the drug oral permeability and to provke its anti-mycobacterium activity. Thin film hydration method was used to formulate NAR-loaded EMLs adopting a 23-full factorial design. The investigated variables were: tripalmitin amount (mg) (A), cholesterol amount (mg) (B), and the percentage of Tween 80 (v/v%) (c). The analyzed responses for EMLs were entrapment efficiency percent (EE %), particle size (PS), and zeta potential (ZP).<br/>Numerical optimization by Design-Expert® software was adopted to choose the optimum formula with respect to the highest EE%, ZP (as absolute value), and the lowest PS and PDI. The optimum formula was exposed to additional in vitro characterization as differential scanning calorimetry (DSC), X-ray diffraction (XRD), transmission electron microscopy (TEM), the effect of storage, in vitro cellular drug uptake and detection of the Minimal Inhibitory Concentration (MIC). Comparative cellular drug uptake and anti-mycobacterial activity studies of the optimum formula relative to the free drug were investigated.<br/>The optimum emulsomal formula (F5) containing 60 mg tripalmitin, 10 mg cholesterol and 0 % Tween 80 with the uppermost desirability value (0.872) revealed EE% (80.5 ± 2.6%), PS (208.5 ±10.1 nm), and ZP (-38.5± 1.9mV). The optimum formula of EMLs (F5) demonstrated enhanced in vitro cellular drug uptake at 30 and 120 min (207.99 ± 2.25 ng/ml and 2135.56 ± 7.33 ng/ml) respectively compared to pure NAR (72.69 ± 0.85 ng/ml and 477.55 ± 0.86 ng/ml respectively) when tested on caco2 cells. The previous outcomes proved the ability of EMLs to enhance the oral permeability and anti-mycobacterium activity of NAR loaded into EMLs (F5) was approximately five times more effective than pure Ethambutol HCl (EMB) as standard drug and pure NAR. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
يعتبر الدرن من الأمراض المعدية التي يمكن أن تكون سائدة في البلدان النامية، والتي انتشرت مؤخرًا مرة أخرى. علاج مرض الدرن صعب لأنه يواجه العديد من العقبات مثل المقاومة البكتيرية للمضادات الحيوية وتسبب جرعات الأدوية المتزايدة في حدوث مضاعفات وآثار جانبية. على الرغم من وجود بدائل طبيعية، إلا أنها تعاني من انخفاض قابلية الذوبان والتوافر البيولوجي. الحاملات النانومترية الحويصلية موثوق بها للتغلب على صعوبات العوامل المضادة للميكروبات ولتعزيز تقديم علاجات الدرن عن طريق الفم. يعتبر الدرن الناجم عن المتفطرات يمثل أعظم الأمراض الجرثومية الخطرة التي تؤثر على الصحة العامة.<br/> يمتلك النارنجنين إمكانات واعدة في صناعة المستحضرات الصيدلانية للنارنجينين، ناتجة عن نشاطها الفارماكولوجي الواسع خاصة المضاد للميكروبات الذي يشمل اختراق الغشاء البكتيري وتحفيز موت الخلية. ومع ذلك، فإن عيبه الرئيسي هو انخفاض قابليته للذوبان المائي الذي يقل عن 0.46 ميكروغرام / مل وتعرضها للتكسيربالانزيمات في مسارها الاول.<br/>وبشكل عام، يمكن أن تؤثر القابلية المنخفضة للذوبان في الماء بشكل كبير على نشاط الدواء، والتوافر البيولوجي، والخصائص.<br/>هدفت هذه الرسالة إلى التغلب على تلك القيود من خلال إعداد أنظمة نانوية قائمة على الدهون: الإيمالزومات. تمت دراسة العديد من العوامل من حيث النسبة المئوية لكفاءة الحصر (EE٪)، وحجم الجسيمات (PS)، وجهد زيتا (ZP) لاختيار الصيغ المثلى التي خضعت لدراسات مختلفة في المختبر للتأكد من ملاءمتها ونشاطها. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Issues CD |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
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| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Methods of administering durgs |
| Source of heading or term |
qrmak |
| 653 ## - INDEX TERM--UNCONTROLLED |
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| Uncontrolled term |
Emulsomes |
| -- |
lipid-based drug delivery systems |
| -- |
entrapment efficiency |
| -- |
resistance |
| -- |
lymphatic targeting |
| -- |
bioavailability |
| -- |
Naringenin |
| -- |
bioavailability |
| -- |
emulsomes |
| -- |
permeability |
| -- |
tuberculosis |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Maha Mohamed Amin |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Yehia Zakaria |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
|---|
| Grant date |
01-01-2023 |
| Supervisory body |
Maha Mohamed Amin |
| -- |
Mohamed Yehia Zakaria |
| Universities |
Cairo University |
| Faculties |
Faculty of Pharmacy |
| Department |
Department of Pharmaceutics and Industrial Pharmacy |
| 905 ## - Cataloger and Reviser Names |
|---|
| Cataloger Name |
Shimaa |
| Reviser Names |
Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |
