Aminoglycoside Modifying Enzymes Detection In Strains Of Pseudomonas Implicated In Different Types Of Infections / (Record no. 169419)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05386namaa2200433 i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033344.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241212s2023 ua a|||f |m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.01 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.01 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.07.Ph.D.2023.Mo.A. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mohamed Mahmoud Kamel Abd-Ellatif, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Aminoglycoside Modifying Enzymes Detection In Strains Of Pseudomonas Implicated In Different Types Of Infections / |
| Statement of responsibility, etc. | By Mohamed Mahmoud Kamel Abd-Ellatif; Supervisors Professor Dr. Nada Nabil Nawar, Professor Dr. Amal Mohammed ElSayed, Dr. Noha Salah ElDein ElSayed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الكشف عن الإنزيمات المتحورة للأمينوجليكوزيد في سلالات السيدوموناس الموجودة فى مختلف انواع العدوى / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 169 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 112-169. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Aminoglycosides are important components of antipseudomonal chemotherapy. The inactivation of drugs by modifying enzymes is the most common mechanism of aminoglycoside resistance. The aim of this study was to examine the prevalence of aminoglycoside modifying enzyme genes in clinical isolates of Pseudomonas aeruginosa at Cairo University Hospitals (Japanese pediatric hospital) with respect to the site of infection and microbial resistance of the strains.<br/>Methods: A cross-sectional study was carried out on all Pseudomonas aeruginosa isolates collected from May 2017 to July 2018 until 100 resistant isolates which are resistant to one or several aminoglycosides were selected. Antimicrobial susceptibility tests (using the disk diffusion method) were performed. In addition, all isolates were screened for the presence of modifying enzyme genes (aac(3)-I and aac(6)-Ib) by polymerase chain reaction.<br/>Results: The resistance rates, as determined by the disk diffusion method, were as follows: tobramycin 100%, gentamicin 98% and amikacin 77%. PCR results revealed that the presence of aac(6′)-Ib was (17 %) among all P. aeruginosa isolates while for aac (3)-I gene the percentage was (1%).<br/>Conclusion: Coordinated efforts and further research works are needed to control antibiotic resistance to aminoglycosides before being a threatening crisis<br/><br/> |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | مقدمه: الأمينوجليكوزيدات هي عنصر مهم في العلاج الكيميائي المضاد للسيدوموناس. يعد تعطيل الأدوية عن طريق تعديل الإنزيمات الأكثر شيوعًا لمقاومة الأمينوجليكوزيدات.<br/>الهدف من الدراسة هو فحص انتشار جينات الإنزيم المعدلة للأمينوجليكوزيد في العزلات السريرية من السيدوموناس ايريجينوزا في مستشفيات جامعة القاهرة (مستشفى الأطفال الياباني) فيما يتعلق بموقع العدوى والمقاومة الميكروبية للسلالات.<br/>المنهج: أجريت هذه الدراسة على كل عينات السيدوموناس ايريجينوزا في الفترة من مايو 2017 الى يوليو 2018 حتى تم عزل 100 من العزلات المضاده لواحد او أكثر للأمينوجليكوزيدز <br/>تم إجراء اختبارات الحساسية لمضادات الميكروبات (باستخدام طريقة انتشار القرص). بالإضافة إلى ذلك، تم فحص جميع العزلات لوجود جينات إنزيم معدلة<br/> بواسطة تفاعل البلمرة المتسلسل.(aac(3)-I and aac(6)-Ib)<br/> نتائج البحث: معدلات المقاومة، كما تحددها طريقة انتشار القرص، على النحو التالي:توبراميسسن 100%، جينتاميسين 98% و اميكاسين 77%. أظهرت نتائج تفاعل البلمرة المتسلسل وجود الجين aac(6)-Ib في 17 % من جميع عزلات السيدوموناس ايريجينوزا بينما كانت بالنسبة للجين aac(3)-I في 1 % فقط.<br/>الخلاصة: هناك حاجة إلى جهود منسقة وأعمال بحثية إضافية للسيطرة على مقاومة المضادات الحيوية للأمينوجليكوزيدات قبل أن تصبح أزمة خطيرة.<br/><br/> |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Clinical and Chemical Pathology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Aminoglycoside modifying enzyme genes |
| -- | Pseudomonas aeruginosa |
| -- | polymerase chain reaction |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nada Nabil Nawar |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amal Mohammed ElSayed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Salah ElDein ElSayed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Nada Nabil Nawar |
| -- | Amal Mohammed ElSayed |
| -- | Noha Salah ElDein ElSayed |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Clinical and Chemical Pathology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Eman El gebaly |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.12.2024 | 89671 | Cai01.11.07.Ph.D.2023.Mo.A. | 01010110089671000 | 12.12.2024 | 11.12.2024 | Thesis |