Study of the association between SIRT1 single nucleotide gene variant and corticosteroid response in Egyptian pediatric patients with primary immune thrombocytopenia / (Record no. 169673)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04402namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033352.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241223s2023 |||a|||f |m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.07 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.07 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.07.M.Sc.2023.Om.S. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Omnia Attia Saad, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Study of the association between SIRT1 single nucleotide gene variant and corticosteroid response in Egyptian pediatric patients with primary immune thrombocytopenia / |
| Statement of responsibility, etc. | By Omnia Attia Saad; Supervised By Prof. Dr. Nevine Mohamed Bahaa Eldin Fouad, Asst. Prof. Marwa Abd Elhady Abd Elsamad, Dr. Doaa Salah Mahmoud |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فى الاطفال SIRT 1 دراسة ارتباط تعدد الجينى لجين المصرين المصابين بمرض نقص الصفائح الدموية المناعى ومدي الاستجابه للعلاج بالكورتيزون / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 93 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) -Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 76-90. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Primary immune thrombocytopenia (ITP) is an autoimmune disorder <br/>characterized by decreased platelet count. While corticosteroids are a useful first-<br/>line therapy for ITP patients, their long-term effectiveness is limited, and the <br/>determinants of corticosteroid sensitivity in ITP patients remain largely unknown. <br/>Silent information regulator 1 (SIRT1) is a histone deacetylase of nicotinamide <br/>adenine dinucleotide (NAD+), which mainly exists in the nucleus, and is a member <br/>of a family of well-studied mammalian sirtuins. SIRT1 interacts with protein <br/>substrates in a variety of signaling pathways (such as Wnt and Notch), participates <br/>in the regulation of most of the body’s physiological functions, and plays a central <br/>regulatory role in cell proliferation, differentiation, senescence, apoptosis, and <br/>metabolism.it is also related to the anti-inflammatory effect of corticosteroids. <br/>Aim of the Work: The present work was done to study the prevalence and role of <br/>SIRT1 SNP rs12778366 in ITP susceptibility and corticosteroids sensitivity. <br/>Participants and Methods: Sixty patients with ITP as well as 60 age and sex-<br/>matched normal healthy controls were included. SIRT1 rs12778366 SNP was <br/>determined by allelic discrimination Taqman real-time PCR. <br/>Results: Our study revealed that SIRT1 rs12778366 variants among ITP patients <br/>were found to be the wild type T/T (81.7%), the heterozygous T/C (16.7%) and the <br/>homozygous C/C genotype (1.7%), while among the control group were the wild <br/>type T/T (90%), the heterozygous T/C (10%) and non were in the homozygous C/C <br/>with no statistically significant difference between the 2 groups (p ˃0.05) and that <br/>SIRT1 rs12778366 variants had no role as a risk factor of ITP susceptibility. <br/>Regarding sensitivity to corticosteroids, patients who were sensitive to steroids <br/>were found to be the wild type T/T (90%), the heterozygous T/C (10%) and non <br/>were in the homozygous C/C, while ITP patients who were resistant to <br/>corticosteroids, the wild type T/T (73.3%), the heterozygous T/C (23.3%) and the <br/>homozygous C/C (3.3%) with no significant difference between the 2 groups (p <br/>˃0.05) and that SIRT1 rs12778366 variants had no impact on prognosis or <br/>treatment outcome. <br/>Conclusion: SIRT1 rs12778366 had no role in ITP susceptibility, disease severity <br/>or corticosteroid sensitivity. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pathology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Immune thrombocytopenic purpura |
| -- | SIRT1 rs12778366 |
| -- | gene variants |
| -- | Taqman RT-PCR |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Mohamed Bahaa Eldin Fouad |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Abd Elhady Abd Elsamad |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Doaa Salah Mahmoud |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Nevine Mohamed Bahaa Eldin Fouad |
| -- | Marwa Abd Elhady Abd Elsamad |
| -- | Doaa Salah Mahmoud |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Clinical and Chemical Pathology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Nourhan |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 23.12.2024 | 89583 | Cai01.11.07.M.Sc.2023.Om.S. | 01010110089583000 | 23.12.2024 | 23.12.2024 | Thesis |