MARC details
| 000 -LEADER |
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| fixed length control field |
07021namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - أخر تعامل مع التسجيلة |
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| control field |
20250120154705.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
250104s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloguing agency |
EG-GICUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GICUC |
| Modifying agency |
EG-GICUC |
| Description conventions |
rda |
| 041 0# - LANGUAGE CODE |
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| Language code of text/sound track or separate title |
eng |
| Language code of summary or abstract |
eng |
| -- |
ara |
| 049 ## - Acquisition Source |
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| Acquisition Source |
Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
615.6 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) |
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| Classification number |
615.6 |
| Edition number |
21 |
| 097 ## - Degree |
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| Degree |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
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| Local Call Number |
Cai01.08.09.Ph.D.2024.Om.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
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| Authority record control number or standard number |
Sherien Magdy Aly Kamel Aly Bakry, |
| Preparation |
preparation. |
| 245 12 - TITLE STATEMENT |
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| Title |
A comparative phytochemical and biological study of certain Ficus L. species (Fam. Moraceae) growing in Egypt / |
| Statement of responsibility, etc. |
by Sherien Magdy Aly Kamel Aly Bakry ; Supervision of Prof. Dr. Meselhy Ragab Meselhy, Prof. Dr. Essam Abdel-Sattar, Prof. Dr. Mona El Said Kassem, Prof. Dr. Mona El Said Kassem, Prof. Dr. Asmaa Fathy Mohamed. |
| 246 15 - VARYING FORM OF TITLE |
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| Title proper/short title |
/ دراسة التأثيرات محتملة الفائدة لﻺعطاء المتزامن ﻷدوية مختارة لمعالجة مرض السكري و أحد المغذيات في حيوانات محدث بها مرض السكري تجريبياّ |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
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| Date of production, publication, distribution, manufacture, or copyright notice |
2024. |
| 300 ## - PHYSICAL DESCRIPTION |
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| Extent |
180 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
25 cm. + |
| Accompanying material |
CD. |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Source |
rda content |
| 337 ## - MEDIA TYPE |
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| Media type term |
Unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Source |
rdacarrier |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography: pages 151-180. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Ficus species (Moraceae) have been utilized for nutrition and traditional medicine, and plants of this family are rich in bioactive natural products. Characterizing the phytochemistry of Ficus species is still challenging due to the inherent complexity of the plant metabolomes and the incomplete decoding of their chemical space. Therefore, in this study, we used molecular networking to clarify the chemical classes present in the leaves of three Ficus species (F. deltoidea Jack, F. drupacea Thunb, and F. sycomorus L.), and molecular networking was used to analyze their chemotaxonomy. Using computational approaches, 90 metabolites from various classes (phenolic acids, flavonoids, furanocoumarins, fatty acids, and terpenoids) were annotated. Phenolic acids were identified as the main class found in the three species. While furanocoumarins were suggested to be present in F. sycomorus, flavonoids-C-glycosides, flavonoids-O-glycosides, and isoflavonoids were the main chemical components of F. drupacea and F. sycomorus. Vomifoliol-based sesquiterpenes were proposed in F. deltoidea. Using SCOT and ISSR markers, the chemotaxonomic difference was consistent with DNA fingerprinting, where F. deltoidea displayed a distinct chemical fingerprint and genotype.<br/> Among the three species, the 70% alcoholic extract of F. drupacea Thunb leaves demonstrated the most potent anti-acid and anti-Helicobacter pylori activities. The active extract was fractionated by Diaion® HP20 column chromatography into 5 fractions; H2O, 25% MeOH/H2O, 50% MeOH/H2O, 75% MeOH/H2O, and 100% MeOH. Among the tested fractions, the Ficus drupacea water fraction (FDWF) was the most active as an anti-acid, anti-H. pylori and anti-urease. So, the gastroprotective effect of FDWF against ethanol-induced peptic ulcer in rats was evaluated. Twenty-three compounds in FDWF were tentatively identified by UPLC-PDA-ESI-MS/MS; the majority of which were phenolic acids and their derivatives. Using LC-ESI-MS/MS, FDWF was standardized to contain 23.66±2.62 mg/g of quinic acid and 8.86±0.29 mg/g of chlorogenic acid. Moreover, molecular interactions of the compounds with the active site of the urease enzyme were supported by the molecular docking analysis where dihydroxybenzoic acid-O-pentoside/hexoside and dihydroxybenzoic acid-O-dipentoside showed the highest binding affinity and very favorable absorption, distribution, metabolism, and excretion (ADME), and drug-likeness properties. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
يزداد انتشار وحدوث داء السكري من النوع 2 عالمياً بصورة متزايده. ومن المتوقع ان يصبح داء السكري السبب السابع المؤدي للوفاة بحلول عام 2030 وفقا ﻷحدث التقديرات الصادرة عن منظمة الصحة العالمية. التوت اﻷزرق غني باﻷنثوسيانين، يوجد اهتمام بهذه المركبات بسبب<br/> آثارها العﻼجية والمفيدة المحتملة من مضادات<br/>اﻷكسدة ، ومضادات اﻻلتهابات ، ووقاية الكبد ، ومضادة لمرض السكري ،. لذلك ، يهدف البحث الحالي الي دراسة اﻵثار المستفادة المحتملة للعﻼج<br/>المتزامن لمستخلص فاكهة التوت اﻷزرق %25) أنثوسيانين( 200)مجم/كجم( مع ألوجلبتين 10)مجم/كجم( أو فوغليبوز 0.1) مجم/كجم( عن طريق الفم على التوالي لمدة ثﻼثة أسابيع لمرض السكري المستحدث باستخدام مادة اﻻستربتوزوتوسين 45) مجم/كجم( في التجويف<br/>البريتوني في الجرذان. وتم قياس مستوي ك ِل من<br/>الجلوكوز، بيبتيد سي، الكوليستيرول الكلي،<br/>الدهون الثﻼثية، إنزيمات الكبد، إنزيمات الكلى، معامل التنكرز الورمي ألفا في المصل. وفي<br/>الوقت نفسه ، تم تحديد محتوى ألفا جلوكوزيداز، نشاط الكاتﻼز، نشاط ديسموتاز الفائق، محتوى<br/>بيروكسيد الدهون في أنسجة كبد الفئران. أحدث استخدام مستخلص فاكهة التوت البري متزامنا مع فوغليبوز في تحقيق السيطرة الكافية على نسبة السكر في الدم عن طريق الحد بشكل كبير من اﻻلتهاب ، واﻹجهاد التأكسدي ، و زيادة الكوليستيرول الكلي و الدهون الثﻼثية. حدث تحسن ملحوظ في مستوي الجلوكوز وبيبتيد سي عند تناول مستخلص فاكهة التوت متزامنا مع فوغليبوز وهذا التحسن كان أفضل من التأثير<br/>المنفرد لكل منهما. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Issues CD |
Issues also as CD. |
| 546 ## - LANGUAGE NOTE |
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| Text Language |
Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| Topical term or geographic name entry element |
Drug treatment |
| Source of heading or term |
qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
DNA fingerprint |
| -- |
Ficus species |
| -- |
in-vitro anti-H. pylori |
| -- |
in-vitro anti-urease enzyme |
| -- |
in vivo gastroprotective |
| -- |
metabolites |
| -- |
molecular docking |
| -- |
pharmacokinetics |
| -- |
phenolic acids |
| -- |
UPLC-Q/TOF-MS |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Omnia El-Sayed Baheg |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Sanaa Abdel Baky Kenawy |
| Relator term |
thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yousreya Aly Aly Maklad |
| Relator term |
thesis advisor. |
| 900 ## - Thesis Information |
|---|
| Grant date |
01-01-2024 |
| Supervisory body |
Omnia El-Sayed Baheg |
| -- |
Yousreya Aly Aly Maklad |
| -- |
Sanaa Abdel Baky Kenawy |
| -- |
Nesrine Salah Eldin Elsayed |
| Universities |
Cairo University |
| Faculties |
Faculty of Pharmacy |
| Department |
Department of Pharmacology and Toxicology |
| 905 ## - Cataloger and Reviser Names |
|---|
| Cataloger Name |
Shimaa |
| Reviser Names |
Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
| Edition |
21 |
| Suppress in OPAC |
No |
