Evaluation of the Effect of HOS Test on Asthenozoospermia Patients and ICSI Outcomes/ (Record no. 170214)
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| fixed length control field | 09024namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250123161501.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250115s2023 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 590 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 590 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.21.M.Sc.2023.Ka.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Karim Tawfik Ahmed Fayed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of the Effect of HOS Test on Asthenozoospermia Patients and ICSI Outcomes/ |
| Statement of responsibility, etc. | Karim Tawfik Ahmed Fayed ; Supervisors: Prof. Dr. Abdel Wahab El Ghareeb, Dr. Heba Ali Abdel El Rahman, Prof. Mostafa Fouad Gomaa. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم تأثير اختبار الهوس على المرضى الذين يعانون من عدم حركة الحيوانات المنوية ونتائج الحمل المجهرى/ |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 139 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) -Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 106-139. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In vitro fertilization (IVF) technique that involves injecting a <br/>single sperm cell directly into the cytoplasm of an egg. This method is <br/>used to prepare gametes for the creation of embryos that will be <br/>transferred to the mother's uterus. In natural sperm selection in humans <br/>is a rigorous process resulting in the highest quality sperm reaching, <br/>and having an opportunity to fertilize the oocyte. In ICSI or IVF the <br/>male partner provides a sperm sample on the same day when the eggs <br/>are collected .<br/>Before to ICSI, sperm selection and capacitation in vitro must <br/>be completed. This apart from the most popular in vitro sperm <br/>capacitation techniques (swim-up, simple wash, filtration, and density <br/>gradients) certain recent techniques are extremely effective and <br/>stronger to the previous ones.<br/>ICSI has been proven to show the same efficiencies as in vitro <br/>fertilization (IVF), a simpler technique where the oocytes, after pickup, are left with the prepared sperm sample overnight and fertilization <br/>occurs following a sort of natural sperm selection . Nowadays, ICSI is <br/>the most used technique infertility treatments in developed countries, <br/>replacing IVF as the first choice .<br/>ICSI is nowadays widely used in couples with severe male-factor <br/>infertility and it is extensively demonstrated that it improves the <br/>fertilization and pregnancy rates when motile spermatozoa are used.<br/>However, for patients with complete asthenozoospemia, although reported <br/>in only 1 of 5000 men, fertility prognosis is very poor, even with ICSI.so <br/> Summary <br/>104<br/>we use Hos test as method of sperm selection in male partner have poor <br/>motility and consider as asthenospermia patient according to WHO 2021 <br/>6<br/>TH Edition.<br/>Conclusion In this study we evaluate the HOST Effect on <br/>Asthenozoospermia Patients and Intra cytoplasmic Sperm Injection <br/>Outcomes.<br/>The HOS Test: Hypo-osmotic swelling test is economical test <br/>which helps in the evaluation of the structural and functional integrity <br/>of spermatozoa. It‘s based on the principle of liquid transports across <br/>the cell membrane under hypo osmotic conditions to get the <br/>equilibrium on both sides of cell membrane .This behavior is frequently <br/>referred to as "tail curling." The ballooning of the plasma membrane is <br/>what causes the curl.<br/>The plasma membrane of the sperm is examined using the HOS <br/>test to ascertain its structural integrity. The experiment is based on the <br/>observation that under hypo-osmotic conditions, fluid can move across <br/>an intact cell membrane before the cell's interior and outside are at <br/>equilibrium. The cell will enlarge as a result of the fluid inflow, <br/>pushing the plasma membrane outward. Normally, the plasma <br/>membrane forms a tight seal around the fibers (axonemal complex) of <br/>the sperm tail. Curling or bending of the tail fibers within the plasma <br/>membrane will take place when the plasma membrane expands under <br/>hypo-osmotic conditions. HOS Test is based on the swelling ability of <br/>functioning sperms after being exposed to the hypo osmotic solution.<br/> Summary <br/>105<br/>Spermatozoa with defected in function of cell membrane do not swell <br/>and their tails do not invagination.<br/>The results of comparison outcome of HOS and NO HOS <br/>test of sperm selection in ICSI cycles: This study carried on 100 <br/>patients in ICSI cycles according to Inclusion criteria where ages of <br/>males and females with good hormonal profile, Males with reduced <br/>sperm motility asthenospermia patient confirmed diagnosis with <br/>infertility and Patients with HOS test positive semen profile. Statistics<br/>of the results showed there was no significant difference between the <br/>HOS and NO HOS groups regarding the fertilization rates, blastulation <br/>quality and pregnancy outcomes (67.7 % VS 72.4%; 70.8% VS 60.9% <br/>and 40% VS 34% respectively). However, no statistical significant <br/>difference between the HOS and no HOS groups regarding oocytes <br/>injected (P =0.001) almost equally oocytes number in ICSI, to avoid <br/>any factors which may affect the results. After this statistics, we <br/>obtained that HOS has better results than NO HOS test in terms of <br/>embryos quality, grade A embryos and pregnancy outcomes. Therefore, <br/>if broader, multi-infertility center randomized studies confirm these <br/>favorable impacts on embryo quality and ICSI outcomes, HOS could be <br/>thought of as the best routine on a regular basis for sperm selection <br/>before ICSI. Finally we have achieved our main goal from the study;<br/>which is getting the best protocol for sperm selection in ICSI which <br/>give the best embryos quality for embryo transfer and increase <br/>pregnancy rate in cases of infertility. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تقنية الإخصاب في المختبر (IVF) التي تتضمن حقن خلية منوية واحدة مباشرة في سيتوبلازم البويضة. تستخدم هذه الطريقة لتحضير الأمشاج لتكوين الأجنة التي سيتم نقلها إلى رحم الأم. الهدف من العمل: لتقييم تأثير العائل على مرضى استسقاء النطاف ونتائج حقن الحيوانات المنوية داخل السيتوبلازم. المريض والطرق: أجريت هذه الدراسة على 100 مريض في دورات الحقن المجهري وفقًا لمعايير التضمين حيث أكدت أعمار الذكور والإناث ذوي المظهر الهرموني الجيد والذكور الذين يعانون من ضعف حركة الحيوانات المنوية ومرضى وهن النطاف تشخيصهم بالعقم والمرضى الذين يعانون من اختبار HOS إيجابية للسائل المنوي. النتائج: لم يكن هناك فرق معتد به بين مجموعتي HOS و NO HOS فيما يتعلق بمعدلات الإخصاب وجودة التفجير ونتائج الحمل (67.7٪ مقابل 72.4٪ ؛ 70.8٪ مقابل 60.9٪ و 40٪ مقابل 34٪ على التوالي). ومع ذلك ، لا يوجد فرق ذو دلالة إحصائية بين مجموعات HOS وعدم وجود مجموعات HOS فيما يتعلق بالبويضات المحقونة (P = 0.001) عدد البويضات بشكل متساوٍ تقريبًا في الحقن المجهري ، لتجنب أي عوامل قد تؤثر على النتائج. الخلاصة: HOS له نتائج أفضل من اختبار NO HOS من حيث جودة الأجنة. أجنة الصف A ونتائج الحمل. لذلك ، إذا أكدت الدراسات العشوائية الأوسع نطاقاً في مركز العقم المتعدد هذه التأثيرات الإيجابية على جودة الجنين ونتائج الحقن المجهري ، يمكن اعتبار HOS أفضل روتين على أساس منتظم لاختيار الحيوانات المنوية قبل الحقن المجهري. أخيرًا لقد حققنا هدفنا الرئيسي من الدراسة ؛ وهو الحصول على أفضل بروتوكول لاختيار الحيوانات المنوية في الحقن المجهري والذي يعطي أفضل جودة للأجنة لنقل الأجنة ويزيد من معدل الحمل في حالات العقم. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Zoology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HOST |
| -- | Asthenozoospermia |
| -- | ICSI |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdel Wahab El Ghareeb |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Heba Ali Abdel El Rahman |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Fouad Gomaa |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Abdel Wahab El Ghareeb |
| -- | Heba Ali Abdel El Rahman |
| -- | Mostafa Fouad Gomaa |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Zoology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Aya Mohamed |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 15.01.2025 | 89867 | Cai01.12.21.M.Sc.2023.Ka.E | 01010110089867000 | 15.01.2025 | 15.01.2025 | Thesis |