Possible role of lncRNA MEG3, lncRNA MAFG-AS1 on miRNA 147 in pathogenesis of Behcet’s disease / (Record no. 170368)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03936namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033416.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250122s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 612.814 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 612.814 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.03.Ph.D.2024.Sh.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Shimaa Mahmoud Abobakr Mahmoud, |
| Preparation | preparation. |
| 245 12 - TITLE STATEMENT | |
| Title | Possible role of lncRNA MEG3, lncRNA MAFG-AS1 on miRNA 147 in pathogenesis of Behcet’s disease / |
| Statement of responsibility, etc. | by Shimaa Mahmoud Abobakr Mahmoud ; Supervised by Prof. Dr. Olfat Gamil Shaker, Dr. Mohamed Tharwat Hegazy, Dr. Ayman Mohamed Hany Shehata. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | الدور المحتمل للرنا الطويل الغير مكود MEG3 والرنا الطويل الغير مكود MAFG-AS1 والرنا الصغير 147 في نشوء مرض بهجت / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 103 pages : |
| Other physical details | illustrations ; |
| Dimensions | 103 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 79-103. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background .Behcet disease (BD) is an autoinflammatory disease characterized by a triad of uveitis, oral and genital aphthae, and described to have altered Toll-like receptors (TLR) on macrophages. It is diagnosed clinically due to the unavailability of any pathognomonic test. If left untreated, it can lead to disability, so early diagnosis and proper management are a must to restrain the inflammation. LncRNA MEG3 and lncRNA MAFG-AS1 are regulators of miRNA 147, induced upon TLR stimulation. Our study suggested them to be possible new biomarkers for BD. However, this needs to be investigated in future in vivo and in vitro studies.<br/>Subjects and methodology<br/>The participants in this study were 100 Egyptian adults who were classified into two groups: fifty BD patients, and fifty age and sex-matched controls. Real- time PCR was used to measure the expression levels of serum LncRNA MEG3, lncRNA MAFG-AS1, and miRNA 147.<br/>Results<br/>LncRNA MEG3 and lncRNA MAFG-AS1 were significantly downregulated in the serum of our BD patients. While serum miRNA 147 was significantly upregulated in BD patients.<br/>Conclusions<br/>It can be concluded that lncRNA MEG3, lncRNA MAFG-AS1, and miRNA147 are promising diagnostic markers and therapeutic targets for BD patients. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | مرض بهجت هو مرض ذاتي المناعة يتميزبوجود قرح بالفم والأعضاء التناسلية والتهاب بالعين. يوصف بوجود متغيرات TLR علي الخلايا الأكلة الكبيرة. يتم تشخيصه اكلينيكيا لغياب اختبار مميز له. أذا تم تركه دون علاج يؤدى الى اعاقة لذلك سرعة التشخيص والعلاج ضرورة للحد من الإلتهاب . الرنا الطويل الغير مكود MEG3 والرنا الطويل الغير مكود MAFG-AS1 منظمين للرنا الصغير 147 الذى ينتج عن اثارة TLR. دراستنا تقترحهم كوسيلة جديدة لتشخيص مرض بهجت. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Medical Biochemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Behcet’s disease |
| -- | lncRNA MEG3 |
| -- | lncRNA MAFG-AS1 |
| -- | miRNA147 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil Shaker |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Tharwat Hegazy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Mohamed Hany Shehata |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Olfat Gamil Shaker |
| -- | Mohamed Tharwat Hegazy |
| -- | Ayman Mohamed Hany Shehata |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Medical Biochemistry and Molecular Biology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 22.01.2025 | 90290 | Cai01.11.03.Ph.D.2024.Sh.P | 01010110090290000 | 22.01.2025 | 22.01.2025 | Thesis |