Studies on palladium and organotin(IV) complexes of homopiperazine / (Record no. 170523)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06050namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033421.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250201s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 546 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 546 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.09.Ph.D.2024.Am.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Amira Mohamed Abd El-Wahab, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Studies on palladium and organotin(IV) complexes of homopiperazine / |
| Statement of responsibility, etc. | by Amira Mohamed Abd El-Wahab ; Supervisors Prof. Dr. Mohamed M. Shoukry, Prof. Dr. Mohamed R. Shehata, Dr. Perihan A. Khalaf- Alla. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسات على متراكبات البالديوم والقصدير الرباعي مع الهوموببرازين / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 236 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 216-229. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | [M(HP)Cl2] is isolated in a solid state and characterized by different tools of analysis, where M = [Pd(II), Sn(IV) in the form of dibutyltin(IV) and diphenyltin(IV)] and HP = 1,4-diazacycloheptane(homopiperazine) as a ligand. Also, the thesis includes the calculations of proton–ligand association constant and the formation constants of binary and ternary complexes. The ternary complexes were formed as a result of the interaction between [Pd(HP)(H2O)2]2+ and some selected bio-relevant ligands as amino acids, peptides, DNA constituents and dicarboxylic acids using potentiometric technique and the non-linear computer program Miniquad-75 at 25ºC and 0.1 M ionic strength using NaNO3.The most predominant species of the formed complexes in the physiological range (pH of blood) were determined by plotting the speciation diagrams. The effect of temperature on the protonation equilibria of homopiperazine, the hydrolysis constant of [Pd(HP)(H2O)2]2+ and formation constants of dibutyltin(IV)-homopiperazine complex are investigated in addition to the calculation of the activation parameters (∆Hº,∆Sº and ∆Gº). Also, the determination of the electronic absorption spectra of some chelates is carried out. Density Functional Theory (DFT) as theoretical calculations have been carried out to know the most stable geometries of the ligand and its complexes with Pd(II) and Sn(IV). On the other side, antimicrobial activity and antitumor activity against breast cancer cell lines were screened in vitro. The carcinogenic activities of the complexes are compared to that of the free homopiperazine. Finally, the docking active sites of interactions were reported |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تم فصل [M(HP)Cl2] فى الحالة الصلبة والتحقق من تكوينه بأدوات التحليل المختلفة , M تشير الى البلاديوم الثنائي والقصدير الرباعي فى شكل القصدير ثنائي الفينيل أو القصدير ثنائي البيوتيل أما HP يمثل الليجاند ويسمي 1،4-ديازاسيكلوهيبتان (homopiperazine) . الرسالة تتضمن أيضا حسابات ثابت ارتباط البروتون –الليجند وثوابت تكوين المجمعات الثنائية والثلاثية. المتراكبات الثلاثية تكونت نتيجة لأتحاد [Pd(HP)(H2O)2]2+ مع بعض الليجاندات المختارة و المهمة بيولوجيًا مثل وحدات DNA ، الببتيدات، الأحماض ثنائية الكربوكسيل والأحماض الأمينية، باستخدام تقنية قياس الجهد وبرنامج الكمبيوتر Miniquad-75 عند 25 درجة مئوية وقوة أيونية 0.1 م باستخدام محلول صوديوم نيترات. تم تحديد الأنواع السائدة للمجمعات المتكونة في النطاق الفسيولوجي (الرقم الهيدروجيني للدم) من خلال رسم التوزيعات التركيزيه لكافة المتراكبات speciation diagrams . تم دراسة تأثير درجة الحرارة على ثابت الاتزان للمتراكب [Pd(HP)(H2O)2]2+ وثوابت تكوين المتراكب dibutyltin(IV)-homopiperazine بالإضافة الى حساب المتغيرات الحرارية <br/> (∆Hº, ∆Sº and ∆Gº) . أيضا تم عمل التحليل الطيفي لبعض المتراكبات المختارة . وتمت حسابات نظرية الكثافة الوظيفية (DFT) للهيموبيبرازين ومتراكباته مع البلاديوم والقصدير من أجل معرفة الشكل الهندسى الأكثر أستقرارا. من ناحية أخرى ، تم فحص النشاط المضاد للميكروبات والنشاط المضاد للأورام ضد سرطان الثدي في المختبر. تمت مقارنة بين نشاط المتراكبات كمضادات للسرطان ونشاط الهوموبيرازين الحر كمضاد للسرطان. أخيرًا، تم تقييم تفاعلات موقع الالتحام النشط باستخدام ( docking). |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Inorganic Chemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Complex-formation equilibria |
| -- | homopierazine |
| -- | Pd(II) |
| -- | dibutyltin and diphenyltin |
| -- | amino acid |
| -- | peptides |
| -- | DNA units |
| -- | Dcarboxylic acids |
| -- | DFT |
| -- | antitumor and antimicrobial activity |
| -- | docking studies |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed M. Shoukry |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed R. Shehata |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Perihan A. Khalaf-Alla |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Mohamed M. Shoukry |
| -- | Mohamed R. Shehata |
| -- | Perihan A. Khalaf-Alla |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 01.02.2025 | 90325 | Cai01.12.09.Ph.D.2024.Am.S | 01010110090325000 | 01.02.2025 | 01.02.2025 | Thesis |