Berberine, a possible therapeutic remedy for experimentally-induced polycystic ovarian syndrome (PCOS) in rats / (Record no. 170581)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05714namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033424.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250203s2024 |||a|||f |m|| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.6 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.6 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.09.M.Sc.2024.Sh.B. |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Shahd Mohamed Salah Eldin Abdul Hamid, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Berberine, a possible therapeutic remedy for experimentally-induced polycystic ovarian syndrome (PCOS) in rats / |
| Statement of responsibility, etc. | By Shahd Mohamed Salah Eldin Abdul Hamid; Under the supervision of Dr. Dalia Moustafa Darwish El-Tanbouly, Dr. Mostafa Elsayed Elnaggar, Dr. Reham Mohamed Essam Mohamed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | بربرين, دواء علاجي محتمل لمتلازمة تكيس المبايض المتعدد المحدثة تجريبياً في الجرذان / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 64 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) -Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 43-64. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Polycystic Ovary Syndrome (PCOS) is a widespread endocrinal disease with no definite cure to date. Fingers are pointed to cyclic adenosine monophosphate (cAMP) as a possible common culprit in both increased steroidogenesis and reduced autophagy in PCOS pathogenesis. Berberine (BBR) is an isoquinolone derivative of natural origin that was used for centuries as an inducer of ovulation. The current study was performed to shed light on the possible effect of BBR in managing PCOS through targeting ovarian cAMP level. Rats were assigned into 4 groups: Control, PCOS induced by 1mg/kg oral letrozole for 23 days, BBR low (95mg/kg) and high (190mg/kg) doses administered for 4 weeks after PCOS induction. BBR ameliorated PCOS as evidenced by histological picture and modulating serum hormonal profile. Moreover, BBR hampered cAMP/protein kinase A (PKA) levels to attenuate abnormal steroidal enzymes (steroidogenic acute regulatory protein (StAR), CYP11A, CYP17A, CYP19A). In parallel, BBR induced an expressive decrement in the cAMP effector, the exchange protein directly activated by cAMP (Epac) and consequently phospholipase C (PLC), inositol triphosphate receptor (IP3R) as well as calpain levels to induce autophagy as evident by the marked rise in the microtubule-associated protein light chain 3 (LC3II/LC3I) ratio. Therefore, BBR could serve as a potential candidate for halting PCOS progression through interfering with cAMP action. It impedes both PKA and Epac axes which are master regulators of steroidogenesis and autophagy, an effect that could serve, in part, as a possible novel explanation for the beneficial role of BBR in treating PCOS. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | متلازمة تكيس المبايض المتعدد(PCOS) هو مرض منتشر ولا يوجد له علاج حتى اليوم. يتسبب احادي فوسفات الأدينوزين (cAMP) في زيادة تكوين الستيرويدات في المبيض و خفض الالتهام الذاتي.<br/>بربري (BBR) هو مشتق من نبات طبيعي تم استخدامه على مدار قرون طويلة كعلاج لتحريض الاباضة. تهدف هذه الدراسة الي تسليط الضوء الى دور البربرين في علاج متلازمة تكيس المبايض المتعدد عن طريق تقليل مستوى احادي فوسفات الادينوزين الحلقي.<br/>تم تقسيم 32 جرذاً من فصيلة ويستار البيضاء الى 4 مجموعات: مجموعة ظابطة, مجموعة مثلث نموذجاً للمتلازمة, مجموعة تلقت جرعة قليلة من البربرين(95 mg/kg) و مجموعة تلقت جرعة عالية من البربرين(190 mg/kg) .<br/>ادي علاج البربرين الي تحسين التشريح المبيضي المرضي و تقليل الانحرافات الهرمونية و ايضاً قلل البربرين التعبير عن الانزيمات المساعدة لتكوين الستيرويدات في المبيض (StAR, CYP11A and CYP17A) و نشاط الانزيم CYP19A <br/>اظهر العلاج بالبربرين انخفاضاً في مستوى بروتين التبادل المنشط بواسطة احادي فوسفات الادينوزين الحلقي (Epac) , فوسفوليباز (PLC), مستقبل الاينوزيتول ثلالثي الفوسفات (I3PR) و مؤشر الالتهام الذاتي كالباين و تعزيز نسبة سلسلة البروتين الخفيفة المرتبطة بالانيبيبات الدقيقة (LC3II/LC3I) و بالتالي يمكن استنتاج اهمية و دور البربرين في تقليل تقدم المتلازمة عن طريق التدخل في عمل احادي فوسفات الادينوزين الحلقي |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issued also as CD |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmacology |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | PCOS |
| -- | Letrozole |
| -- | Berberine |
| -- | Steroidogenesis |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dalia Moustafa Darwish El-Tanbouly |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Elsayed Elnaggar |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reham Mohamed Essam Mohamed |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Reham Mohamed Essam Mohamed |
| -- | Mostafa Elsayed Elnaggar |
| -- | Dalia Moustafa Darwish El-Tanbouly |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmacology and Toxicology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Nourhan |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 03.02.2025 | 90315 | Cai01.08.09.M.Sc.2024.Sh.B. | 01010110090315000 | 03.02.2025 | 03.02.2025 | Thesis |