FABP1 as an early marker of diabetic nephropathy in type 2 diabetic patients and its Gene mutation relation to metabolic syndrome / (Record no. 170592)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05173namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033425.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250203s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.4624 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.4624 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.11.18.Ph.D.2024.Mo.F |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mona Mustafa Kamal Mahmoud, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | FABP1 as an early marker of diabetic nephropathy in type 2 diabetic patients and its Gene mutation relation to metabolic syndrome / |
| Statement of responsibility, etc. | by Mona Mustafa Kamal Mahmoud ; Supervised By Prof.Mohamed Momtaz Mohamed, Prof. Olfat Gamil shaker, Dr.Hend Abdallah Elsheimy, Dr.Hussein Hassan Samir. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | كعامل للاكتشاف المبكر للاعتلال الكلوي في مرضى الداء السكري من النوع الثاني و علاقه طفرته الجينيه بمتلازمه الأيض FABP1 / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 117 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 101-115. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: The prevalence of diabetes mellitus, a worldwide burden, is expected to affect more than 350 million people by 2035, About one-third of diabetic patients have microalbuminuria after 15 years of disease duration, and nearly half of them develop real kidney disease, Early detection and intervention are essential in the prevention and treatment of diabetic nephropathy (DN). LFABP( u-LFABP) has been demonstrated to be a marker of tubular damage., Several studies have shown that u-LFABP could be a useful marker for the detection of early stage of DN. But the levels of u-LFABP at different stages of DN among type 2 diabetic patients are unknown<br/>Objectives: <br/>The aim of this study is to :<br/> Assess if FABP1 is an early marker of diabetic nephropathy in type 2 diabetic patients,<br/> Find out relation of FABP1 to (eGFR,Lipid profile,BMI and HbA1c).<br/> Find relations between FABP1 gene mutation and metabolic syndrome components including the following:<br/>• Lipid profile and hypertension.<br/>• Anthropometric measures (Wc and BMI).<br/>• HbA1c and fasting plasma glucose .<br/><br/>Methods: This is a cross sectional study 120 diabetic patients (40 with norm albuminuria, 40 micro albuminuria and 40 macroalbuminuric was conducted at El-Kasr Aini Cairo University Hospital. The patients were recruited from the outpatient clinics of endocrinology and internal medicine. Detailed medical history, complete physical examination for type II diabetic patients aged (35-65) years old., Laboratory investigations including; Fasting blood glucose, blood urea, serum creatinine, HbA1c and lipid profile for all participants. Estimated GFR will be measured by Modification of Diet in Renal Disease (MDRD) equation, The relation between morning spot urine sample ACR and urinary FABP1 will be studied, also FABP1 urinary level will be correlated to (eGFR, HbA1c, lipid profile). <br/> And the relation between FABP1 gene T94A mutations to metabolic syndrome components will be studied<br/><br/>Results: FABP1 isn’t an early marker of diabetic nephropathy and it’s urinary level had not significant relation to (lipid profile, HbA1c ,BMI and eGFR).<br/>Its gene mutation had significant relation to Fasting plasma glucose and HbA1c and was not related to other components metabolic syndrome<br/><br/> Conclusions: <br/> FABP1 couldn’t be used as an early marker of diabetic nephropathy, Also FABP1 urinary level wasn’t statistically correlated to (lipid profile,HbA1c,BMI,WC and eGFR ; We didn’t find any statistically significant relation between the gene polymorphism and lipid profile (TG,LDL,HDL,total cholesterol ).<br/> We didn’t find significant relation between the gene mutation and anthropometric measures including (WC and BMI).<br/> the gene polymorphism had no statistically significant relation to hypertension .<br/> We found statistically significant relation between the gene polymorphism and Fasting plasma glucose.<br/> To the best of our knowledge we are the first study to report that polymorphism had significant relation to HbA1C and albuminuria.,but it hadn’t significant relation to eGFR and urea |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Diabetic nephropathies. |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Diabetetic nephropathy |
| -- | FABP1 |
| -- | rs2919782 gene polymorphism |
| -- | metabolic syndrome |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Momtaz Mohamed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Olfat Gamil shaker |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hend Abdallah Elsheimy |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hussein Hassan Samir |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Mohamed Momtaz Mohamed |
| -- | Olfat Gamil shaker |
| -- | Hend Abdallah Elsheimy |
| -- | Hussein Hassan Samir |
| Universities | Cairo University |
| Faculties | Faculty of Medicine |
| Department | Department of Internal Medicine |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| Reviser Names | Huda |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 03.02.2025 | 90356 | Cai01.11.18.Ph.D.2024.Mo.F | 01010110090356000 | 03.02.2025 | 03.02.2025 | Thesis |