Design, Synthesis, and Biological Evaluation of Some Novel Heterocyclic Derivatives as Anticancer Targeting Agents / (Record no. 170769)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03761namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250225121148.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250211s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.19 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.04.M.Sc.2024.Na.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Nada Mohamed Reda Mohamed EL-Saied, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Design, Synthesis, and Biological Evaluation of Some Novel Heterocyclic<br/>Derivatives as Anticancer Targeting Agents / |
| Statement of responsibility, etc. | by Nada Mohamed Reda Mohamed EL-Saied ; Supervision of Prof. Dr. Eman Mohamed Ahmed Mostafa, Prof. Dr. Khaled Omar Ahmed Mohamed, Dr. Amira Atef Ahmed Helwa. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم وتشييد وتقييم بيولوجي لبعض المشتقات الحلقية غير المتجانسة كعوامل مستهدفة مضادة للسرطان / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 66 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 13-15. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This thesis comprises three chapters in addition to summaries in English and Arabic.<br/>The first chapter: General introduction, which consists of a brief literature survey of cancer, pyrimidine derivatives, and their cytotoxic activity, Epidermal Growth Factor Receptor Enzyme (EGFR), COX-2, PI3k, and their inhibitors.<br/>The second chapter: Design, synthesis, and biological evaluation of new<br/>pyrimidine-5-carbonitrile derivatives as novel anticancer, dual EGFRWT/COX-2 inhibitors with docking studies. <br/>The third chapter: Novel Pyrimidine-5-Carbonitriles as Potential Apoptotic and Antiproliferative Agents by Dual Inhibition of EGFRWT/T790Mand PI3k Enzymes; Design, Synthesis, Biological Evaluation, and Docking Studies<br/> |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تتألف هذه الرسالة العلمية من ثلاثة فصول بالإضافة إلى ملخص وخاتمة باللغتين العربية والإنجليزية يليها بعض التوصيات.<br/>الفصل الأول: مقدمة عامة.<br/>الفصل الثاني: تصميم وتشييد وتقييم بيولوجي لمشتقات جديدة من البيريميدين-5-كاربونيتريل كعوامل مضادة للسرطان ومثبطات مزدوجة لـ EGFRWT/ COX-2مع دراسة عملية محاكاة النمذجة الجزيئية للمركبات. <br/>الفصل الثالث: تصميم وتشييد وتقييم بيولوجي لمشتقات جديدة من البيريميدين-5-كاربونيتريل كعوامل محتملة محفزة لموت الخلايا المبرمج ومضادة لتكاثر الخلايا السرطانية ومثبطات مزدوجة لـ EGFRWT/T790M/PI3kمع دراسة عملية محاكاة النمذجة الجزيئية للمركبات. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pharmaceutical chemistry |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pyrimidine derivatives |
| -- | Design |
| -- | synthesis |
| -- | anticancer |
| -- | EGFR |
| -- | COX-2 |
| -- | PI3K |
| -- | Molecular Docking |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Eman Mohamed Ahmed Mostafa |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Khaled Omar Ahmed Mohamed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Amira Atef Ahmed Helwa |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Eman Mohamed Ahmed Mostafa |
| -- | Khaled Omar Ahmed Mohamed |
| -- | Amira Atef Ahmed Helwa |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Pharmaceutical Organic Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Eman Ghareeb |
| Reviser Names | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2025 | 90420 | Cai01.08.04.M.Sc.2024.Na.D | 01010110090420000 | 11.02.2025 | 11.02.2025 | Thesis |