Studying the correlation between carbapenem resistant Acinetobacter baumannii infections and diabetes / (Record no. 170850)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05677namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223033433.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250215s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.329 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.329 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.08.06.M.Sc.2024.Ay.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Aya Mustafa Mahmoud Ghareeb, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Studying the correlation between carbapenem resistant Acinetobacter baumannii infections and diabetes / |
| Statement of responsibility, etc. | by Aya Mustafa Mahmoud Ghareeb ; Supervision Dr. Reham Samir, Dr. Marwa Mahmoud Raafat, Dr. Naglaa Bazan. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسه العلاقة ما بين بكتيريا الراكده البومانيه المقاومه للمضاد الحيوي كاربابينيم و المرضى المصابين بداء السكري / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 167 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 116-167. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Treatment of multidrug resistant Acinetobacter baumannii (A. baumannii) is considered one of the critical problems worldwide especially carbapenem resistant A. baumannii that has become a major issue globally.<br/>The aim of this study was to investigate the development of A. baumannii resistance over the years among diabetic and non-diabetic Egyptian patients, detect carbapenem resistance genes, determine the effectiveness of the available monotherapy for treating A. baumannii, and assess the effect of different antibiotic combinations.<br/>The study was divided into two parts. Retrospective study conducted from January 2018 to December 2019 which involved collecting data from 54 A. baumannii infected patients’ profile. The second part was prospective study carried out from February 2021 to November 2022 and included 45 A. baumannii isolates.<br/>All collected isolates were identified phenotypically and genotypically. Antibiotic susceptibility tests were conducted using disc agar diffusion and broth microdilution methods. The isolates were screened for OXA-23, GES, VIM, and NDM carbapenem-resistant genes. Four different antibiotic combinations were evaluated using double-disk synergy and checkerboard methods.<br/>The results reveal that multidrug resistance of A. baumannii progressively increased over time, rising from 56% in 2018 to 95.6% in 2022. Additionally, carbapenem resistance increased, reaching 87% to 100% for imipenem and meropenem in 2021 and 2022.<br/>The A. baumannii isolates from diabetics showed resistance to imipenem,meropenem, and doripenem at a value of 68.8%, 61.8%, and 47.4%, respectively, while those from non-diabetics showed resistance of 97.9%, 83.3%, and 50%,respectively. All isolates had at least two carbapenem resistance genes including<br/>OXA-23, GES, VIM and NDM. VIM was the most prevalent gene in diabetic patients (100%) and non-diabetic patients (96.15%). Tigecycline and meropenem combination showed 50% synergistic activity in diabetic and 66.7% in non- |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تم تحديد أربع مجموعات من المضادات الحيوية كل مجموعه بستخدم فيها أثنين من المضادات الحيويه معاً ثم تم تحديد مدى فعاليتهم باستخدام اختبار التآزر المزدوج للأقراص و باستخدام طرق رقعة الشطرنج.<br/>أثبتت الدراسة ان مقاومة الأدوية المتعددة يزيد بشكل تدريجي مع مرور الوقت، حيث ارتفعت نسبه المقاومه من ٥٦% في عام٢٠١٨ إلى٦,٩٥ % في عام٢٠٢٢. <br/>بالإضافة إلى ذلك، مع مرور الوقت، زادت أيضًا مقاومة البكتريا البومانية <br/>الكاربابينيم، حيث وصلت إلى٨٧% إلى ١٠٠% في الإيميبينيم والميروبينيم <br/>في عامي ٢٠٢١و ٢٠٢٢<br/>. وقد لوحظت مقاومة للإيميبينيم والميروبينيم والدوريبينيم في مرضى السكر بنسبة ٨,٦٨% و٨,٦١% و٤,٤٧% وفي غير المصابين بالسكري بنسبة ٩,٩٧% و ٣,٨٣% و٥٠ % ،على التوالي. و هذه العينات لديها على الاقل اثنين من جينات <br/>OXA-23، VIM ،وNDM GES المقاومة للكاربابينيم من حيث<br/>و يمثل ١٠٠% في المرضى المصابين بالسكري VIM كان الجين الأكثر انتشار هو<br/>و بنسبة ١٥,٩٦% في مرضى الغير مصابين بالسكر. <br/>كما تم تقييم مجموعة المضادات الحيوية للتيجيسيكلين والميروبينيم. بلغ النشاط التآزري ٥٠% في مرض السكري و٧,٦٦ % للغير مصابين بمرض السكري. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Drugs extracted from microorganisms |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | A. baumannii |
| -- | antibiotics combinations |
| -- | carbapenem resistance genes |
| -- | diabetes |
| -- | multi-drug resistance |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Reham Samir |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Mahmoud Raafat |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Bazan |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Reham Samir |
| -- | Marwa Mahmoud Raafat |
| -- | Naglaa Bazan |
| Universities | Cairo University |
| Faculties | Faculty of Pharmacy |
| Department | Department of Microbiology and Immunology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 15.02.2025 | 90462 | Cai01.08.06.M.Sc.2024.Ay.S | 01010110090462000 | 15.02.2025 | 15.02.2025 | Thesis |