Analytical study of some repurposed pharmaceutical compounds as potential treatment for COVID-19 / (Record no. 170855)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04484namaa22004211i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250219094600.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250215s2023 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.1 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 615.1 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.08.M.Sc.2023.Sh.A |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Sherif Gamal Abdelreheem Ismail, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Analytical study of some repurposed pharmaceutical compounds as potential treatment for COVID-19 / |
| Statement of responsibility, etc. | by Sherif Gamal Abdelreheem Ismail ; Supervisors Prof. Dr. Said A. Salih, Prof. Dr. Gehad G. Mohamed, Prof. Dr. Asmaa A. Mandour. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة تحليلية لبعض المستحضرات الصيدليه المعاد استخدامها كعلاج محتمل ل كوفيد19 / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2023. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 82 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.)-Cairo University, 2023. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 68-82. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Sofosbuvir/ledipasvir (SOF/LDV), a combination of antiviral drugs, has been recently repurposed for COVID-19 management, according to Food and Drug Administration approval. Paracetamol (PAR) identified as a first-line antipyretic for COVID-19 symptoms’ management. The use of these three drugs together has significantly influenced the management of COVID-19 by providing symptomatic relief via inhibiting viral activity. A validated ultra-high performance liquid chromatographic (UHPLC) method has been introduced for the quantification of these repurposed drugs in COVID-19 treatment. This novel chromatographic method allows the simultaneous detection of SOF, LDV, and PAR in bulk. Additionally, the method has been applied to determine the levels of SOF and LDV in human plasma samples with PAR used as an internal standard. As well as, a simultaneous spectrophotometric determination of recombined SOF, LDV and PAR together has been performed. The methodologies were validated in accordance with some ICH standards. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | تم مؤخرًا إعادة استخدام السوفوسبوفيروالليديباسفير وهو مزيج من الأدوية المضادة للفيروسات، في علاج كوفيد-19، وفقًا لموافقة إدارة الغذاء والدواء. تم تحديد الباراسيتامول كخافض للحرارة في الخط الأول للسيطره علي أعراض كوفيد-19. وقد أثر استخدام هذه الأدوية الثلاثة معًا بشكل كبير على علاج كوفيد-19 من خلال تخفيف الأعراض عن طريق تثبيط النشاط الفيروسي. تم تقديم طريقة كروماتوجرافيا سائلة فائقة الأداء و التحقق من صحتها لتقدير كمية هذه الأدوية المعاد استخدامها في علاج كوفيد-19. تسمح هذه الطريقة الكروماتوجرافية الجديدة بالكشف المتزامن عن السوفوسبوفير،الليديباسفيروالباراسيتامول بكميات كبيرة. بالإضافة إلى ذلك، تم تطبيق الطريقة لتحديد مستويات السوفوسبوفيروالليديباسفير في عينات البلازما البشرية مع استخدام الباراسيتامول كمعيار داخلي. بالإضافة إلى ذلك، تم إجراء تقدير طيفي متزامن للسوفوسبوفير والليديباسفير والباراسيتامول معًا. تم التحقق من صحة المنهجيات وفقًا لبعض معاييرالمجلس الدولي لتنسيق المتطلبات الفنية للمستحضرات الصيدلانيه للاستخدام البشري . |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Durgs |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sofosbuvir |
| -- | Ledipasvir |
| -- | Paracetamol |
| -- | COVID-19 |
| -- | UPLC |
| -- | Spectrophotometry |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Said A. Salih |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gehad G.Mohamed |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Asmaa A. Mandour |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2023 |
| Supervisory body | Said A. Salih |
| -- | Gehad G.Mohamed |
| -- | Asmaa A. Mandour |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Chemistry |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 15.02.2025 | 90467 | Cai01.12.08.M.Sc.2023.Sh.A | 01010110090467000 | 15.02.2025 | 15.02.2025 | Thesis |