Efficiency of eco-friendly new chalcone derivatives against fungal deterioration of some egyptian archaeological objects / (Record no. 170977)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 06478namaa22004451i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250223143038.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250223s2024 |||a|||f m||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 620.1122 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 620.1122 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.12.05.Ph.D.2024.Mo.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Mona Mahmoud Ali Mohamed Soliman, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Efficiency of eco-friendly new chalcone derivatives against fungal deterioration of some egyptian archaeological objects / |
| Statement of responsibility, etc. | by Mona Mahmoud Ali Mohamed Soliman ; Supervisors Prof. Dr. Tarek A. A. Moussa, Prof. Dr. Ismail Abdelshafy Abdelhamid, Prof. Dr. Hamdi Mahmoud Hassaneen, Dr. Rania Ahmed Ali Hassan. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | فعالية مشتقات الشالكون الجديدة الصديقة للبيئة ضد التدهور الفطري لبعض المقتنيات الأثرية المصرية / |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 208 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 182-205. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Ancient Egyptian mummies have attracted people's attention from ancient times to the present day. The negative impact of fungal activity on the deterioration of mummy cartonnage is a global problem, and their conservation is a challenging task. Isolation, molecular identification, and characterization of fungal species involved in the biodeterioration of ancient Egyptian mummy cartonnage located in the El-Lahun area, Fayoum government, Egypt, were conducted. The most dominant of thirteen isolated fungal species is Aspergillus flavus MT874383 (25.7%), followed by A. terreus MT874468 (16.76%), while the least dense one is Athelia bombacina MT874470 (0.56%). The antimicrobial activity of a novel synthesized series of tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline chalcone derivatives was tested in vitro against thirteen isolated fungal species. Chalcone derivative 13 was the most efficient compound causing the maximum significant growth inhibition of all isolated fungal species, followed by chalcone derivatives 4 and 9. The most efficient three selected chalcone derivatives (13, 4, and 9) showed effective inhibition activities on the dry weight, enzymatic activities, and total sugar productivity of the thirteen isolated fungal species. The most active chalcone derivatives were also molecularly docked into the active sites of indicated metabolic enzymes (amylase, cellulase, and protease). X-ray diffraction analysis (XRD), energy dispersive x-ray spectroscopy (EDX), scanning electron microscope (SEM), and Fourier transform infrared spectroscopy (FTIR) were recorded for the tested ancient Egyptian mummy cartonnage. Application of the most efficient chalcone derivatives on experimental aging cartonnage models was carried out to examine the ability of the most dominant isolated fungal species to colonize treated experimental aging cartonnage models |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | المومياوات المصرية القديمة دائما تجذب الانتباه منذ العصور القديمة إلى يومنا هذا. وقد اظهر النشاط الفطري مشكلة عالمية بتأثيره السلبي على تدهور المومياوات والكارتوناج مما أدى الى صعوبة الحفاظ عليها. في هذه الدراسة تم عزل وتعريف وتوصيف الفطريات المسئولة عن التحلل البيولوجي لكارتوناج المومياء المصرية القديمة من منطقة اللاهون في الفيوم، مصر. وقد كانت فطرة أسبرجلس فلافس MT874383 هي أكثر السلالات السائدة من الثلاثة عشر فطر المعزولة من كارتوناج المومياء يتبعها فطرة أسبرجلس تيريس MT874468، في حين أن الأقل كثافة هي فطرة أثيليا بومباسينا MT874470. وقد تم اختبار أثني عشر مركبا جديدا من مشتقات الشالكون (تريازولو - ايزوكينولين) على نمو الثلاثة عشر فطر التي تم عزلها من كارتوناج المومياء المصرية القديمة. كان مركب الشالكون 13 هو المركب الأكثر كفاءة في تثبيط نمو جميع العزلات الفطرية، يليه مشتقات الشالكون 4 و9. وقد أظهرت الثلاثة مركبات (13، 4 و9) الأكثر كفاءة نشاطا تثبيطي على الوزن الجاف والأنشطة الانزيمية وانتاجية السكر للثلاثة عشر نوعا من الفطريات المعزولة. كما أظهرت مشتقات الشالكون الأكثر فعالية التحاما جزيئيا في المواقع النشطة لإنزيمات الأميلاز والسيلولاز والبروتياز. تم الكشف عن مدى التدهور الميكروبي لكارتوناج المومياء المصرية القديمة بحيود الأشعة السينية (XRD)، الاشعة السينية المشتتة (EDX)، المسح المجهري الإلكتروني (SEM) وبالأشعة تحت الحمراء الطيفية (FTIR). وقد تم تطبيق أكثر مشتقات الشالكون كفاءة على نماذج تجريبية متقادمة صناعيا لفحص قدرة أكثر الاجناس السائدة على استعمار هذه النماذج. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Corrosion and damage resistance |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cartonnage |
| -- | biodeterioration |
| -- | chalcone derivatives |
| -- | fungal deterioration |
| -- | Egyptian mummies |
| -- | antifungal activity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Tarek A. A. Moussa |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ismail Abdelshafy Abdelhamid |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hamdi Mahmoud Hassaneen |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Ahmed Ali Hassan |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Tarek A. A. Moussa |
| -- | Ismail Abdelshafy Abdelhamid |
| -- | Hamdi Mahmoud Hassaneen |
| -- | Rania Ahmed Ali Hassan |
| Universities | Cairo University |
| Faculties | Faculty of Science |
| Department | Department of Botany and Microbiology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 23.02.2025 | 90704 | Cai01.12.05.Ph.D.2024.Mo.E | 01010110090704000 | 23.02.2025 | 23.02.2025 | Thesis |