Prognosis and outcome of philadelphia chromosome-positive acute lymphoblastic leukemia pediatric patients at the National Cancer Institute in Egypt / (Record no. 171456)
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| 000 -LEADER | |
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| fixed length control field | 06996namaa22004331i 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - أخر تعامل مع التسجيلة | |
| control field | 20250413130954.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 250413s2024 ua a|||frm||| 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloguing agency | EG-GICUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GICUC |
| Modifying agency | EG-GICUC |
| Description conventions | rda |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| Language code of summary or abstract | eng |
| -- | ara |
| 049 ## - Acquisition Source | |
| Acquisition Source | Deposit |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.94418 |
| 092 ## - LOCALLY ASSIGNED DEWEY CALL NUMBER (OCLC) | |
| Classification number | 616.94418 |
| Edition number | 21 |
| 097 ## - Degree | |
| Degree | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Local Call Number | Cai01.19.05.M.Sc.2024.ES.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Authority record control number or standard number | Esraa Samy Abdel- Hameed, |
| Preparation | preparation. |
| 245 10 - TITLE STATEMENT | |
| Title | Prognosis and outcome of philadelphia chromosome-positive acute lymphoblastic leukemia pediatric patients at the National Cancer Institute in Egypt / |
| Statement of responsibility, etc. | by Esraa Samy Abdel- Hameed ; Supervision Prof. Hossam El Zomor, Prof. Ahmed Ibrahim Elhemaly, Prof. Mona El - Ashry. |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | المستقبل المرضى ونتائج العلاج فى مرضى الأطفال الذين يعانون من سرطان الدم الليمفاوى الحاد الإيجابى لكروموسوم فيلادلفيا فى المعهد القومى للسرطان فى مصر/ |
| 264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE | |
| Date of production, publication, distribution, manufacture, or copyright notice | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 75 pages : |
| Other physical details | illustrations ; |
| Dimensions | 25 cm. + |
| Accompanying material | CD. |
| 336 ## - CONTENT TYPE | |
| Content type term | text |
| Source | rda content |
| 337 ## - MEDIA TYPE | |
| Media type term | Unmediated |
| Source | rdamedia |
| 338 ## - CARRIER TYPE | |
| Carrier type term | volume |
| Source | rdacarrier |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc)-Cairo University, 2024. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE | |
| Bibliography, etc. note | Bibliography: pages 67-72. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The most predominant cancer in the pediatric age category is acute lymphoblastic leukemia (ALL). In Egypt, between 2007 and 2017, a study at Children's Cancer Hospital Egypt-(CCHE) was conducted to assess the incidence and OS of cancer in the hospital, representing about 40-50% of all children of cancer in Egypt. <br/>It has been reported that Philadelphia Chromosome translocation is an uncommon cytogenetic abnormality in pediatric patients with ALL accounting for less than 5%. Pediatric patients with Ph+ ALL have been recognized as high to very high risk patients with poor prognosis and outcome when treated previously with intensive chemotherapy alone or followed by allogenic heamatopiotic stem cell transplantation, hence the Innovation era of tyrosine kinase inhibitors (TKIs) has been related to significant favorable outcome in Ph+ ALL pediatric patients when used concurrently with intensive chemotherapy. <br/>Therefore, the current retrospective study aimed to validate both prognosis and outcome of pediatric patients with Ph+ ALL through assessment of different clinical and pathological prognostic factors on survival rates as overall survival (OS) and event free survival (EFS). <br/>Accordingly Ph+ ALL 27 children their age were ranged from 1-18 years and were recruited from NCI, Egypt, during the period from January 2013 to December 2018 and treated with standard of care protocol, then treatment related toxicities were reported and graded according to Common Terminology Criteria for Adverse Events (CTCAE). <br/>The result of the current result after post induction analyses of bone marrow obtained at Day 42 of total XV protocol revealed that:<br/>• All patients were in CR morphologically, Twenty (74%) patients were <0.1% MRD (CR) by Flow cytometry while 27% failed to achieve CR. FISH analysis was performed post induction with 56% of the patients had MRD >0.01%, while 44% achieved MRD >0.1%.<br/>• Cases failed to achieve complete molecular response with Log Reduction <3.542 were 33% and seventeen patients did not have available molecular log reduction post induction.<br/>Post consolidation results revealed: <br/>• Patients in CR morphologically were twenty-three (85%), and twenty-three patients achieved MRD <0.01 by flow cytometry. Fourteen (52%) patients achieved negative MRD by FISH analysis. <br/>• Post consolidation molecular Log Reduction was <3.5 in 30% of cases while 22% achieved complete molecular response<br/>At the end of treatment, Cr was reported in 67%, and sixteen (59%) patients achieved MRD <0.1% by FC while two patients had MRD >0.01. <br/>Twenty-six (96.3%) patients received TKIs. Initiation TKI time was during induction in 63% of patients, 30% Post Induction and 3.7% post Consolidation. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | أكثر أنواع السرطان السائدة في فئة الأطفال هو لوكيميا ليمفوبلازية حادة (ALL). في مصر، تمت دراسة في مستشفى سرطان الأطفال في مصر (CCHE) بين عامي 2007 و 2017 لتقييم معدل الاحتمال والبقاء على قيد الحياة للسرطان في المستشفى، ممثلة حوالي 40-50٪ من جميع أطفال السرطان في مصر.<br/>تم الإبلاغ عن تحول كروموسوم فيلادلفيا كتغير سايتوجيني نادر في المرضى الأطفال الذين يعانون من ALL ويمثل أقل من 5٪. تم التعرف على المرضى الأطفال الذين يعانون من Ph+ ALL على أنهم مرضى بمخاطر عالية إلى مرتفعة جدًا بتوقعات سيئة ونتائج سيئة عند علاجهم مسبقًا بالعلاج الكيميائي المكثف بمفرده أو بعده تليه زرع الخلايا الجذعية الهيماتوبويتية، وبالتالي فإن عصر الابتكار في مثبطات تيروزين كيناز (TKIs) قد ترتبط بنتائج إيجابية ملحوظة في مرضى الأطفال الذين يعانون من Ph+ ALL عند استخدامها بشكل متزامن مع العلاج الكيميائي المكثف.<br/>لذلك، كانت الدراسة الاستعادية الحالية تهدف إلى تحقيق توقعات ونتائج المرضى الأطفال الذين يعانون من Ph+ ALL من خلال تقييم عوامل التوقعات السريرية والمرضية المختلفة على معدلات البقاء مثل البقاء الكلي (OS) والبقاء الحر من الأحداث (EFS).<br/>وبناءً على ذلك، تم تضمين 27 طفلاً يتراوح عمرهم بين 1-18 عامًا وتم جمعهم من NCI، مصر، خلال الفترة من يناير 2013 إلى ديسمبر 2018 وتم علاجهم بمعايير الرعاية القياسية، ثم تم الإبلاغ عن السموم المتعلقة بالعلاج وتصنيفها وفقًا لمصطلحات الأحداث السلبية المشتركة (CTCAE). |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Issues CD | Issues also as CD. |
| 546 ## - LANGUAGE NOTE | |
| Text Language | Text in English and abstract in Arabic & English. |
| 650 #7 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Leukemia |
| Source of heading or term | qrmak |
| 653 #0 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | acute lymphoblastic leukemia |
| -- | Philadelphia chromosome |
| -- | TKIs |
| -- | outcome |
| -- | pediatric oncology |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hossam El Zomor |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ahmed Ibrahim Elhemaly |
| Relator term | thesis advisor. |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mona El - Ashry |
| Relator term | thesis advisor. |
| 900 ## - Thesis Information | |
| Grant date | 01-01-2024 |
| Supervisory body | Hossam El Zomor |
| -- | Ahmed Ibrahim Elhemaly |
| -- | Mona El - Ashry |
| Universities | Cairo University |
| Faculties | National Cancer Institute |
| Department | Department of Pediatric Oncology |
| 905 ## - Cataloger and Reviser Names | |
| Cataloger Name | Shimaa |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Edition | 21 |
| Suppress in OPAC | No |
| Source of classification or shelving scheme | Home library | Current library | Date acquired | Inventory number | Full call number | Barcode | Date last seen | Effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 13.04.2025 | 90875 | Cai01.19.05.M.Sc.2024.ES.P | 01010110090875000 | 13.04.2025 | 13.04.2025 | Thesis |