Structure-based design and synthesis of novel Ý-carboline derivatives and their biological evaluation as phosphodiesterase 5 inhibitors and anticancer agents / (Record no. 42427)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01869cam a2200289 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223030817.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 130403s2011 ua h f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Gift |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.34.M.Sc.2011.Am.S |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Amal Hassan Ali Hassan |
| 245 10 - TITLE STATEMENT | |
| Title | Structure-based design and synthesis of novel Ý-carboline derivatives and their biological evaluation as phosphodiesterase 5 inhibitors and anticancer agents / |
| Statement of responsibility, etc. | Amal Hassan Ali Hassan ; Supervised Ashraf H. Abadi , Nermin Salah Ahmed |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | التصميم القائم على الهيكل و تشييد مشتقات جديدة من البيتا كاربولين و تقييمهم الأحياني كمثبطات لإنزيم فوسفوداي إستريز ٥ و كعوامل مضادة للسرطان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Amal Hassan Ali Hassan , |
| Date of publication, distribution, etc. | 2011 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 98 Leaves : |
| Other physical details | facsimiles ; |
| Dimensions | 30cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Tadalafil, a Ý-carboline derivatives that has been introduced to the market for treatment of Male Erectile Dysfunction, acts through inhibition of Phosphodiesterase 5, leading to elevation of cGMP, vascular relaxation in the corpora cavernosa and penile erection during sexual stimulation. The safety, tolerability of PDE5 inhibition as well as the involvement of cGMP as a key component in itracellular signaling may provide new therapeutic applications for this class of drugs |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ashraf Moustafa Kamal Hassan Abadi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nermin Salah Ahmed , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type |
|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الثقاقات الاجنبية - الدور الثالث | 11.02.2024 | Cai01.34.M.Sc.2011.Am.S | 01010110060172000 | 05.07.2024 | Thesis |