MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02895cam a2200313 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
141014s2014 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.08.09.M.Sc.2014.Mo.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Abdelaziz Mahmoud Ibrahim |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Pharmacological study of the possible therapeutic effect of certain natural and synthetic drugs in experimentally induced osteoporosis in rat / |
| Statement of responsibility, etc. |
Mohamed Abdelaziz Mahmoud Ibrahim ; Supervised Azza M. Agha , Osama Elshabrawy |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
دراسة فارماكولوجية للتاثير الدوائى المحتمل لبعض المواد الطبيعية و المشيدة فى هشاشة العظام المحدثة معمليا فى الجرذان |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Mohamed Abdelaziz Mahmoud Ibrahim , |
| Date of publication, distribution, etc. |
2014 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
120 P. : |
| Other physical details |
charts , facsimiles ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The current study investigated the antiosteoporotic effects of linseed and fish oils as natural sources of polyunsaturated fatty acids on ovariectomy-induced osteoporosis as compared to alendronate sodium; a nitrogen containing bisphosphonate in this model of experimental osteoporosis. Rats were rendered osteoporotic through bilateral ovariectomy and kept on AIN-93 modified diet for 20 weeks. Linseed oil (90 and 180 mg/kg, p.o), fish oil (90 and180 mg/kg, p.o), and alendronate sodium (3 mg/kg, p.o) were administered to rats for 8 weeks. Efficacy of tested agents was judged based on the estimation of serum calcium (Ca+2), phosphorus, osteocalcin (OCN), bone alkaline phosphatase (BALP), tartrate resistant acid phosphatase (TRAP), tumor necrosis factor alpha (TNF-Ü), as well as histopathological examination of bone sections. Besides, bone mineral densities (BMD) of femur, tibia, and spine were measured by dual x-ray absorptiometry to evaluate the effect of the tested drugs on calcium deposition in bone. Linseed and fish oils hampered serum levels of Ca+2, OCN, BALP, TRAP, and TNF-Ü after both 4 and 8 weeks of its administration to the osteoporotic rats along with an increment in serum phosphorus and femur, spine, and tibia BMD as compared to alendronate sodium. Linseed oil and to a better extent fish oil possess promising anti-osteoporotic effects comparable to alendronate that might be attributed to their contents of polyunsaturated fatty acids. Hence, it can be recommended to use them in osteoporotic patients |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
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| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Linseed oil |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Osteoporosis |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Ovariectomy |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Azza M. Agha , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Osama Elshabrawy , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
