MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02308cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150113s2014 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
EG-GiCUC |
| Language of cataloging |
eng |
| Transcribing agency |
EG-GiCUC |
| 041 0# - LANGUAGE CODE |
|---|
| Language code of text/sound track or separate title |
eng |
| 049 ## - LOCAL HOLDINGS (OCLC) |
|---|
| Holding library |
Deposite |
| 097 ## - Thesis Degree |
|---|
| Thesis Level |
Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) |
|---|
| Classification number |
Cai01.11.07.Ph.D.2014.Ya.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Yasmin Yehia Helmy Khater |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Evaluation of CYP17 and ERÜ genes polymorphisms in the risk of breast cancer development / |
| Statement of responsibility, etc. |
Yasmin Yehia Helmy Khater ; Supervised Nadida Abdelhamid Gohar , Dina Farouk Elgayar , Mohamed Shehata Mohamed Abdallah |
| 246 15 - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
تقييم مخاطر الأشكال المتعددة لجين الصبغ الخلوي 17 وجين مستقبل الإستروجين ألفا في حدوث سرطان الثدي |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Cairo : |
| Name of publisher, distributor, etc. |
Yasmin Yehia Helmy Khater , |
| Date of publication, distribution, etc. |
2014 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
152 P. ; |
| Dimensions |
25cm |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Introduction: Breast cancer is the most frequent malignancy among women worldwide. It is a multifactorial disease related to genetic, environmental and life style factors that influence the level of exposure to estrogen which may play a central role in breast cancer development. Most breast cancers are likely to be caused by low penetrance genes. CYP17 gene which encode the enzyme P450c17Ü playing a key role in estrogen biosynthesis and ERÜ gene which play an important role in mammary epithelial cells proliferation and tumorigenesis are among this susceptibility genes. The T{u2192}C substitution in the promotor region of CYP17 gene which creates a restriction site for the MspA1 restriction enzyme may lead to overexpression of this gene and higher action of the enzyme. Also, Xba1 polymorphism in the ERÜ gene may alter the activity of the ER affecting susceptibility to breast cancer |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE |
|---|
| Additional physical form available note |
Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
Breast cancer estrogen |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
CYP17: cytochrome P450 17Ü hydroxylase gene |
| 653 #4 - INDEX TERM--UNCONTROLLED |
|---|
| Uncontrolled term |
P450C17: 17Ü hydroxylase/17 |
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Dina Farouk Elgayar , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Mohamed Shehata Mohamed Abdallah , |
| Relator term |
|
| 700 0# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Nadida Abdelhamid Gohar , |
| Relator term |
|
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Aml |
| Reviser |
Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) |
|---|
| Cataloger |
Nazla |
| Reviser |
Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |
| Koha item type |
Thesis |
