Design and synthesis of some rimonabant congeners of anticipated pharmacological activity as cannabinoid receptor modulators / (Record no. 49496)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02265cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 150221s2014 ua o f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.08.05.Ph.D.2014.Es.D |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Essam Eldin Abdelfattah Osman |
| 245 10 - TITLE STATEMENT | |
| Title | Design and synthesis of some rimonabant congeners of anticipated pharmacological activity as cannabinoid receptor modulators / |
| Statement of responsibility, etc. | Essam Eldin Abdelfattah Osman ; Supervised Samir M. Elmoghazy , Mohamed M. Hussein , Sahar Mahmoud AbouSeri |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تصميم و تشييد بعض مشابهات الريمونابانت من المتوقع أن يكون لها فاعلية أقربازينية على مستقبلات الكانابينويد |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Essam Eldin Abdelfattah Osman , |
| Date of publication, distribution, etc. | 2014 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 216 P. : |
| Other physical details | photographs ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutical Chemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | In this thesis, novel series of cannabinoid receptor modulators were designed. Molecular modeling techniques were used to support the design. Semicarbazone derivatives IIIa-d and thiosemicarbazone IVa- d, Va and Vb and VIIa- e, triazole derivatives XIIIa- q, XIV and XVa and XVb and furan- 3- carbonitrile derivatives XVIIIa- i, XXa- i and XXIIa- c were synthesized. Seventeen target compounds were evaluated in an in vitro functional assay for their agonist and antagonist activities at hCB1 and hCB2 receptors. Fourteen target compounds were evaluated in an affinity binding assay in vitro towards CB1 and CB2 receptors. Compounds IIIb and IVb were CB2 agonists while IIId and IVd were CB2 antagonists. Triazole derivatives XIII were active as CB1 antagonists. Furan -3- carbonitrile XVIII and XX were variably binding to both receptor subtypes |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cannabinoid receptors |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Molecular modeling |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Rimonabant |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Mahmoud Hussein , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sahar Mahmoud AbouSeri , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Samir Mohamed Elmoghazy , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.08.05.Ph.D.2014.Es.D | 01010110064583000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.08.05.Ph.D.2014.Es.D | 01020110064583000 | 22.09.2023 | CD - Rom | 64583.CD |