Pharmacokinetics of cefquinome in healthy and pasteurella multocida infected rabbits following oral and intramuscular administration and Its interaction with flunixin meglumine / (Record no. 53070)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02784cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031329.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151103s2015 ua f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.10.15.Ph.D.2015.Ha.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Hassan Ahmed Mohamed Shaheen |
| 245 10 - TITLE STATEMENT | |
| Title | Pharmacokinetics of cefquinome in healthy and pasteurella multocida infected rabbits following oral and intramuscular administration and Its interaction with flunixin meglumine / |
| Statement of responsibility, etc. | Hassan Ahmed Mohamed Shaheen ; Supervised Mostafa Abbas Shalaby , Ayman Goudah Mostafa , Gehan Mohamed Kamel |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | المسارالحركي لدواء سيفوكينوم فى الأرانب السليمة والمصابة بميكروب الباستريلا ملتوسيدا بعد ا{uئإئ٩}عطاء عن طريق الفم والحقن العضلى وتداخله مع فلونوكسين ميجلومين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Hassan Ahmed Mohamed Shaheen , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91 P. ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This study aimed to investigate the serum disposition kinetics of cefquinome, a fourth generation cephalosporin, in rabbits following a single intramuscular (IM) injection and single oral (PO) administration at a dose 10 mg/kg b.wt in healthy and Pasteurella multocida-infected rabbits, using a parallel design single dose study. Interaction of cefquinome with flunixin meglumine was also tested. Serum samples of cefquinome were measured using HPLC-MS/MS. The results showed that Serum cefquinome disposition kinetic was best fitted to a two-compartment open model after IM and PO dosage in healthy and Pasteurella multocida-infected rabbits. Following IM, Peaks of cefquinome concentrations (Cmax) were 9.05 ± 0.06 and 8.12 ± 0.11 æg/ml attained at 0.95 ± 0.04 and 1.01 ± 0.08 h (Tmax), respectively. The elimination half-lives were 2.60 ± 0.04 and 2.32 ± 0.06 hrs, respectively. Values of area under the curve were 43.26± 0.69 and 34.69 ± 1.03 {uF06D}g. h/ml, respectively. Mean residence times were 4.12 ± 0.05 and 3.72 ± 0.07 h, respectively. The pharmacokinetic profile of cefquinome displays a good absorption and long elimination half-life in rabbits |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cefquinome |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | HPLC assay |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Pharmacokinetics |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ayman Goudah Mostafa , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Gehan Mohamed Kamel , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mostafa Abbas Shalaby , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Aml |
| Reviser | Cataloger |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.10.15.Ph.D.2015.Ha.P | 01010110066578000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.10.15.Ph.D.2015.Ha.P | 01020110066578000 | 22.09.2023 | CD - Rom | 66578.CD |