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Pharmacokinetics of cefquinome in healthy and pasteurella multocida infected rabbits following oral and intramuscular administration and Its interaction with flunixin meglumine / (Record no. 53070)

MARC details
000 -LEADER
fixed length control field 02784cam a2200349 a 4500
003 - CONTROL NUMBER IDENTIFIER
control field EG-GiCUC
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250223031329.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 151103s2015 ua f m 000 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency EG-GiCUC
Language of cataloging eng
Transcribing agency EG-GiCUC
041 0# - LANGUAGE CODE
Language code of text/sound track or separate title eng
049 ## - LOCAL HOLDINGS (OCLC)
Holding library Deposite
097 ## - Thesis Degree
Thesis Level Ph.D
099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC)
Classification number Cai01.10.15.Ph.D.2015.Ha.P
100 0# - MAIN ENTRY--PERSONAL NAME
Personal name Hassan Ahmed Mohamed Shaheen
245 10 - TITLE STATEMENT
Title Pharmacokinetics of cefquinome in healthy and pasteurella multocida infected rabbits following oral and intramuscular administration and Its interaction with flunixin meglumine /
Statement of responsibility, etc. Hassan Ahmed Mohamed Shaheen ; Supervised Mostafa Abbas Shalaby , Ayman Goudah Mostafa , Gehan Mohamed Kamel
246 15 - VARYING FORM OF TITLE
Title proper/short title المسارالحركي لدواء سيفوكينوم فى الأرانب السليمة والمصابة بميكروب الباستريلا ملتوسيدا بعد ا{uئإئ٩}عطاء عن طريق الفم والحقن العضلى وتداخله مع فلونوكسين ميجلومين
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Cairo :
Name of publisher, distributor, etc. Hassan Ahmed Mohamed Shaheen ,
Date of publication, distribution, etc. 2015
300 ## - PHYSICAL DESCRIPTION
Extent 91 P. ;
Dimensions 25cm
502 ## - DISSERTATION NOTE
Dissertation note Thesis (Ph.D.) - Cairo University - Faculty of Veterinary Medicine - Department of Veterinary Pharmacology
520 ## - SUMMARY, ETC.
Summary, etc. This study aimed to investigate the serum disposition kinetics of cefquinome, a fourth generation cephalosporin, in rabbits following a single intramuscular (IM) injection and single oral (PO) administration at a dose 10 mg/kg b.wt in healthy and Pasteurella multocida-infected rabbits, using a parallel design single dose study. Interaction of cefquinome with flunixin meglumine was also tested. Serum samples of cefquinome were measured using HPLC-MS/MS. The results showed that Serum cefquinome disposition kinetic was best fitted to a two-compartment open model after IM and PO dosage in healthy and Pasteurella multocida-infected rabbits. Following IM, Peaks of cefquinome concentrations (Cmax) were 9.05 ± 0.06 and 8.12 ± 0.11 æg/ml attained at 0.95 ± 0.04 and 1.01 ± 0.08 h (Tmax), respectively. The elimination half-lives were 2.60 ± 0.04 and 2.32 ± 0.06 hrs, respectively. Values of area under the curve were 43.26± 0.69 and 34.69 ± 1.03 {uF06D}g. h/ml, respectively. Mean residence times were 4.12 ± 0.05 and 3.72 ± 0.07 h, respectively. The pharmacokinetic profile of cefquinome displays a good absorption and long elimination half-life in rabbits
530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE
Additional physical form available note Issued also as CD
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Cefquinome
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term HPLC assay
653 #4 - INDEX TERM--UNCONTROLLED
Uncontrolled term Pharmacokinetics
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Ayman Goudah Mostafa ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Gehan Mohamed Kamel ,
Relator term
700 0# - ADDED ENTRY--PERSONAL NAME
Personal name Mostafa Abbas Shalaby ,
Relator term
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a>
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Aml
Reviser Cataloger
905 ## - LOCAL DATA ELEMENT E, LDE (RLIN)
Cataloger Nazla
Reviser Revisor
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme Dewey Decimal Classification
Koha item type Thesis
Holdings
Source of classification or shelving scheme Not for loan Home library Current library Date acquired Full call number Barcode Date last seen Koha item type Copy number
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة قاعة الرسائل الجامعية - الدور الاول 11.02.2024 Cai01.10.15.Ph.D.2015.Ha.P 01010110066578000 22.09.2023 Thesis  
Dewey Decimal Classification   المكتبة المركزبة الجديدة - جامعة القاهرة مخـــزن الرســائل الجـــامعية - البدروم 11.02.2024 Cai01.10.15.Ph.D.2015.Ha.P 01020110066578000 22.09.2023 CD - Rom 66578.CD