The prevalence and clinical consequences of vitamin D deficiency and vitamin D receptor polymorphism in Egyptian patients suffering from systemic lupus erythematosus / (Record no. 53165)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03276cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031332.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151108s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.18.Ph.D.2015.Sa.P |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Safa Labib Abdelshakour Emam |
| 245 14 - TITLE STATEMENT | |
| Title | The prevalence and clinical consequences of vitamin D deficiency and vitamin D receptor polymorphism in Egyptian patients suffering from systemic lupus erythematosus / |
| Statement of responsibility, etc. | Safa Labib Abdelshakour Emam ; Supervised Kamel Saad Eldin Heshmat Gado , Hanan Hassan Fouad Ahmed , Rasha Mohamed Abdel Samie{u2019} Abdella |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة عن نقص فيتامين د وتعدد الاشكال الجينية لمستقبلاته والمضاعفات المترتبة على ذلك فى المرضى المصريين المصابين بالذئبة الحمراء |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Safa Labib Abdelshakour Emam , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 187 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objectives: To investigate whether BsmI and FokI VDR gene polymorphisms could be susceptibility markers for SLE in Egyptian patients and to study their association with lupus activity and damage. Methods: Data were collected on 45 SLE patients and 40 healthy controls including demographics,SLE activity and damage. Serum 25(OH)D3 level was assessed. Genotyping for the VDR BsmI and FokI gene polymorphisms was performed by RFLP/PCR for only 34 SLE patients and 16 controls. Results:Lower base level 25(OH)D3 correlated negatively with SLEDAI score, damage score,anti dsDNA and complement consumption.There were no significant differences in genotype and allelic frequencies of FokI and BsmI polymorphisms between SLE patients and controls. There was a significant positive correlation between FokI polymorphisms and SLEDAI score (p = 0.021) and damage score (p = 0.002). There was also a significant association between FokI polymorphisms and the different vitamin D status in SLE patients (p=0.002) with a higher frequency of vitamin D insufficiency and deficiency in SLE patients carrying the FokI F/F genotype compared to those carrying the f/f and F/f genotypes. BsmI polymorphisms did not correlate with SLEDAI score and damage score, but showed significant associations with neuropsychiatric damage and disease activity variables of SLE as low complement, fever and mucosal ulcers. Conclusion : Low levels of vitamin D in SLE patients correlated with increasing disease activity and damage. FokI polymorphisms correlated significantly with SLEDAI score and damage score and showed a significant association with different vitamin D status in SLE patients. |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | 25(OH) D3 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SLE |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | vitamin D receptor Fok1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hanan Hassan Fouad Ahmed , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Kamel Saad Eldin Heshmat Gado , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rasha Mohamed Abdelsamie Abdella , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.18.Ph.D.2015.Sa.P | 01010110066688000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.18.Ph.D.2015.Sa.P | 01020110066688000 | 22.09.2023 | CD - Rom | 66688.CD |