Genetic polymorphisms of TNF-alpha and IL-8 and their impact on the clinical outcome in Egyptian children with sickle cell anemia / (Record no. 53272)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02544cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031335.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151114s2014 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2014.Da.G |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dalia Kamal Hegazy Abdelrahman |
| 245 10 - TITLE STATEMENT | |
| Title | Genetic polymorphisms of TNF-alpha and IL-8 and their impact on the clinical outcome in Egyptian children with sickle cell anemia / |
| Statement of responsibility, etc. | Dalia Kamal Hegazy Abdelrahman ; Supervised Rania Mohamed Fawzy , Ilham Youssry Ibrahim , Nadia Ibrahim Sewelam |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | وتأثيرها فى مرضى انيميا الخلايا المنجليةTNF-alpha and IL- 8 التغيرات الجينية فى |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dalia Kamal Hegazy Abdelrahman , |
| Date of publication, distribution, etc. | 2014 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 142 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Sickle cell disease (SCD) is a disorder characterized by a heterogeneous clinical outcome. In the present study, we investigated the associations between Tumor Necrosis Factor-alpha (TNF-{uF061}) -308G>A and Interleukin 8 (IL-8) -251A>T gene polymorphisms and laboratory data in children with SCD. Results: In the present work, TNFÜ-AA genotype and the mutant A allele were higher in both groups of SCD patients compared to control group. But there was no significant difference detected between steady state and crisis patients regarding TNFÜ-AA genotype or TNFÜ-A allele. As regards IL-8; IL-8 TT genotype and mutant T allele were significantly higher in both groups of SCD patients compared to control group. There was no significant difference detected between steady state and crisis patients regarding IL-8 TT genotype or IL-8 T allele. Conclusion: From these results we can conclude that the presence of TNF-Ü ''-308 G>A" and IL-8 "-251 A>T" polymorphisms is associated with increased risk of morbidity in SCD, but is not associated with increased disease severity |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Alpha and IL-8 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Sickle cell anemia |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TNF |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ilham Youssry Ibrahim , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nadia Ibrahim Sewelam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Rania Mohamed Fawzy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2014.Da.G | 01010110066705000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2014.Da.G | 01020110066705000 | 22.09.2023 | CD - Rom | 66705.CD |