Genetic study of three-prime repair exonuclease (trex1) in the susceptibility to systemic lupus erythematosus (SLE) among Egyptian patients / (Record no. 53572)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02729cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031343.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151128s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.32.M.Sc.2015.Di.G |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Dina Abdelrahman Ibrahim Eldessouki |
| 245 10 - TITLE STATEMENT | |
| Title | Genetic study of three-prime repair exonuclease (trex1) in the susceptibility to systemic lupus erythematosus (SLE) among Egyptian patients / |
| Statement of responsibility, etc. | Dina Abdelrahman Ibrahim Eldessouki ; Supervised Geilan Abdelmoneim Mahmoud , Ghada Mohamed Elhossainy Abdelsalam , Marwa Hassan Niazy |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة وراثية توضح دور تريكس1فى قابلية التأثير لمرض الذئبة الحمراء بين المرضى المصريين |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Dina Abdelrahman Ibrahim Eldessouki , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 146 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Rheumatology and Rehabilitation |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: To find out the role of TREX1 and its variants in the genetic susceptibility to systemic lupus erythematosus (SLE) among Egyptian patients and to correlate the clinical manifestations and important laboratory data in SLE patients with the genetic testing. Results: Our work showed 28 patients with TREX1 polymorphism (c.531C>T) in a total of 50 SLE patients (56%), and in 18 out of 50 in the control group (36%) (p value=0.070). TREX1 polymorphism was present in 56% of SLE patients in group I, while in 36% of SLE cases in group II. The polymorphism was positively associated with neuropsychiatric manifestations and chilblains. There was a statistically significant value in cases with oral ulcers (p value=0.004), photosensitivity (p value=0.047) and seizures (p value=0.029). Conclusion: A recurrent polymorphism (c.531C>T) was found in higher frequency among Egyptian patients in comparison to control group especially in cases with NPSLE, seizures and chilblains; with minor allele frequency of 0.28 in cases and 0.18 in controls. Cases with positive consanguinity & family history showed higher frequency for TREX1 polymorphism, however with no statistical significant difference |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Polymorphism |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | SLE |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | TREX1 |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Geilan Abdelmoneim Mahmoud , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Ghada Mohamed Elhossainy Abdelsalam , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Marwa Hassan Niazy , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.32.M.Sc.2015.Di.G | 01010110066781000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.32.M.Sc.2015.Di.G | 01020110066781000 | 22.09.2023 | CD - Rom | 66781.CD |