Increased integrity of free circulating DNA in sera of patients with colorectal cancer / (Record no. 53602)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02325cam a2200325 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151129s2015 ua d f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | M.Sc |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.11.07.M.Sc.2015.Re.I |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Reem Hasanin Mohamed Ali |
| 245 10 - TITLE STATEMENT | |
| Title | Increased integrity of free circulating DNA in sera of patients with colorectal cancer / |
| Statement of responsibility, etc. | Reem Hasanin Mohamed Ali ; Supervised Dina Farouk Elgyaar , Nevine Ezz Eldin Elabd , Noha Hassan Ibrahim |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | دراسة سلامة الحمض النووى الحر كعلامة بيولوجية مصلية محتملة للكشف عن سرطان القولون و المستقيم |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Reem Hasanin Mohamed Ali , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 147 P. : |
| Other physical details | charts ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Clinical and Chemical Pathology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Cell - free DNA circulating in blood is a candidate biomarker for malignant tumors. Unlike uniformly truncated DNA released from apoptotic non diseased cells, DNA released from dead cancer cells varies in size. To measure the ratio of longer to shorter DNA fragments (DNA integrity) in serum to study it as a potential biomarker for patients with colorectal cancer (CRC). Sera from 50 patients with CRC,10 patients with benign colonic lesions and 20 healthy volunteers were assessed by quantitative real-time PCR of ALU repeats (ALU-qPCR) with 2 sets of primers (115 and 247 bp) amplifying different lengths of DNA. DNA integrity was determined as ratio of qPCR results of ALU 247 - bp over ALU 115-bp. Serum DNA integrity was increased in cases of CRC at different stages indicating highly significant difference from control and premalignant groups (p < 0.001). ROC curves for differentiating CRC from control and from premalignant lesions had areas under the curves of 0.9 and 0.85 respectively |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | ALU - qPCR |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Colorectal cancer |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | DNA integrity |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dina Farouk Elgyaar , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nevine Ezz Eldin Elabd , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Noha Hassan Ibrahim , |
| Relator term | |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Samia |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.11.07.M.Sc.2015.Re.I | 01010110066951000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.11.07.M.Sc.2015.Re.I | 01020110066951000 | 22.09.2023 | CD - Rom | 66951.CD |