Evaluation of glutathione S-transferase M1 genotype and neopterin as prognostic factors in Ý-thalassemia patients / (Record no. 53631)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02965cam a2200349 a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | EG-GiCUC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20250223031345.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 151130s2015 ua dh f m 000 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | EG-GiCUC |
| Language of cataloging | eng |
| Transcribing agency | EG-GiCUC |
| 041 0# - LANGUAGE CODE | |
| Language code of text/sound track or separate title | eng |
| 049 ## - LOCAL HOLDINGS (OCLC) | |
| Holding library | Deposite |
| 097 ## - Thesis Degree | |
| Thesis Level | Ph.D |
| 099 ## - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | Cai01.12.02.Ph.D.2015.As.E |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Asem Metwally Aboshanab Salman |
| 245 10 - TITLE STATEMENT | |
| Title | Evaluation of glutathione S-transferase M1 genotype and neopterin as prognostic factors in Ý-thalassemia patients / |
| Statement of responsibility, etc. | Asem Metwally Abo Shanab Salman ; Supervised Abdelgawad Ali Fahmi , Mohamed Ali Eldosouky , Naglaa Mohamed Kholoussi |
| 246 15 - VARYING FORM OF TITLE | |
| Title proper/short title | تقييم التركيب الوراثى للجلوتاثيون أس-ترانسفيراز أم1 و نيوبترين كعوامل متابعة في مرضى بيتا-ثلاسيميا |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Cairo : |
| Name of publisher, distributor, etc. | Asem Metwally Aboshanab Salman , |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 173 P. : |
| Other physical details | charts , facsimiles ; |
| Dimensions | 25cm |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This work was carried out to investigate the role of Neopterin and GSTM1 polymorphism in prognostic Ý-thalassemia, also to detect the correlation between GSTM1 null genotype and appearance cardiac complications in Ý-thalassemia. Methods: This study was divided to three groups (group I: 20 healthy subjects, group II: 56 Ý-thalassemic patients, group III: 16 Ý-thalassemic patients with cardiac complications). The human neopterin and cytokines were determined by ELISA method, while the measurement of human hs-CRP and Immunoglobulins were performed using nephelometry. GSTM1 genotype was detected by PCR and cardiac complications were determined by Echocardiograph. Results: There were statistically significant increases in Neopterin, IL-6, TNF-Ü, IgA, IgG, IgG subclasses (1, 2, 3 & 4) and hs-CRP levels, but statistically insignificant difference in IL-4 and IgM in Ý- thalassemic patients compared to normal subjects. Results showed no relation between GSTM1 null genotype frequency and Ý-thalassemia or cardiac complications appearance. Also results showed that LV diastolic function was significantly impaired in cases with GSTM1 null genotype in group III. Conclusion: Neopterin can be used as a marker for complications of inflammation and infection in Ý-thalassemia. GSTM1 null genotype frequency has no role in beta-thalassemia or cardiac complication appearance. GSTM1 null genotype has a role in cardiac iron overload and impairing of left ventricular diastolic function |
| 530 ## - ADDITIONAL PHYSICAL FORM AVAILABLE NOTE | |
| Additional physical form available note | Issued also as CD |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Cytokines |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | GSTM1 |
| 653 #4 - INDEX TERM--UNCONTROLLED | |
| Uncontrolled term | Neopterin |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Abdelgawad Ali Fahmi , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mohamed Ali Eldosouky , |
| Relator term | |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Naglaa Mohamed Kholouss , |
| Relator term | |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://172.23.153.220/th.pdf">http://172.23.153.220/th.pdf</a> |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Nazla |
| Reviser | Revisor |
| 905 ## - LOCAL DATA ELEMENT E, LDE (RLIN) | |
| Cataloger | Soheir |
| Reviser | Cataloger |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Koha item type | Thesis |
| Source of classification or shelving scheme | Not for loan | Home library | Current library | Date acquired | Full call number | Barcode | Date last seen | Koha item type | Copy number |
|---|---|---|---|---|---|---|---|---|---|
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | قاعة الرسائل الجامعية - الدور الاول | 11.02.2024 | Cai01.12.02.Ph.D.2015.As.E | 01010110066794000 | 22.09.2023 | Thesis | ||
| Dewey Decimal Classification | المكتبة المركزبة الجديدة - جامعة القاهرة | مخـــزن الرســائل الجـــامعية - البدروم | 11.02.2024 | Cai01.12.02.Ph.D.2015.As.E | 01020110066794000 | 22.09.2023 | CD - Rom | 66794.CD |